Handbook of Pharmaceutical Manufacturing Formulations: Semisolid Products (Volume 4 of 6): Semi-Sol

Handbook of Pharmaceutical Manufacturing Formulations, Semisolid Products ( Vol. 4 of 6) (HANDBOOK OF Pharmaceutical Manufacturing.
Table of contents

Add Lutrol F slowly, and stir until it is dissolved. Heat to room temperature when the air bubbles escape. Strain olive oil through voile cloth or equivalent tion from step 5 into the oil mixture from step 3 into a suitable stainless steel-jacketed tank. While heating oil—stear- 8. Homogenize primary emulsion through a Troy ate mix, add cetyl alcohol, lanolin, petrolatum, Mill, or similar device, into the balance of aque- and polysorbate 40 with mixing.

2nd Edition

Mix until all ous solution, mixing continually under vacuum. Note that the primary emulsion should strained through voile cloth or3. Add and dissolve hexachlorophene in the oil equivalent before being run through the Troy mix, then add and disperse the simethicone. Start heating another jacketed tank as mL 9.

See a Problem?

Add and dissolve under vacuum. Stop mixer, add sodium lauryl sulfate, and con- Reserve 4 mL of solution from step 5 in a separate container to rinse equipment in step 2. Add to step 3 while mixing. Rinse with item 3 and add and mix. Charge items 2 and 4 in a melting vessel and 7. Transfer to storage vessel. Fill appropriate quantity at a suitable temperature. Start mixing at 10 rpm manual mode. Homogenize for 6 minutes using Ultra- Turrax homogenizer. Hydrocortisone Acetate SuppositoriesHydrocortisone acetate is a corticosteroid designated blended hydrogenated vegetable oil base.

Each Anusol-chemically as pregnene-3,dione, acetyloxy - HC mg suppository contains 25 mg hydrocortisone11,dihydroxy- 11 beta. Each rectal suppository con- acetate in a hydrogenated cocoglyceride base. Add and mix item 1 with item 5 balance and add to step 2.


  • Overture c minor D8 - Cello.
  • Danny Baker Record Breaker (4): The Worlds Stickiest Earwax.
  • 1st Edition.
  • The Ice Prince;
  • Shock!.
  • Handbook of Pharmaceutical Manufacturing Formulations, Semisolid Products (Vol. 4 of 6).

Dissolve item 2 in balance of item 9 and a and heat to melt. In a separate vessel, heat two thirds of item 9 for several hours.

Handbook of Pharmaceutical Manufacturing Formulations: Semisolid Products by Sarfaraz K. Niazi

Add to step 1. Each gram of cream ylene.

Desage form

Mix item 1 in Cool down the using homogenizer to make slurry. Add to the dispersed phase while mixing at Rinse the container with Cool add to the dispersed phase. Mix and homogenize under vacuum 0. Mix for 0—15 minutes. Transfer the oil phase to the aqueous phase in ing at 10 rpm. Auto mode, under vacuum 0. Heat the mixture of items 1—5 and the water during cooling to room temperature. Add the water to the obtained solution of items 1—5 with rigorous stirring. Transfer the oil phase from step 2 into step 5 through vacuum transfer while stirring at man Add and dissolve items 9 and 10 in step 3.

Add item 3, balance of item 5, and item 8 and dissolve by mixing for 10—15 minutes at Fill appropriate quantity into collapsible tubes. Semisolid ProductsHydrocortisone Cream and OintmentHydrocortisone provides safe, effective relief of many dif- and white wax. Hydrocortisonepolyethylene glycol, stearamidoethyl diethylamine, and 0.

Add item 8 and continue to stir until the gel is cool. Continue to stir until the gel is cool. Clear col- orless gels. Prepare solution of items 6 and 7 and mix slowly with solution of items 1—5.


  1. ?
  2. .
  3. Change How You Think About Recruiting: The Key to Team Growth!;
  4. .
  5. ;
  6. !
  7. Protein Expression in Animal Cells: 43 (Methods in Cell Biology)!

    8. Form a clear, colorless gel. Charge items 2 and 4 in a melting vessel and 5. Homogenize dispersion under vacuum at2. Transfer the mixture of step 2 to the step Preparation of water phase: Add hydrogen perioxide and dissolve. Mix for 15 minutes with agitation and vacuum2. Preparation of oil phase: While mixing and under vacuum, allow the cetostearyl alcohol, white petrolatum, glycerol mixture to cool gradually to room temperature.


    • Handbook of Pharmaceutical Manufacturing Formulations: Sterile Products - CRC Press Book?
    • Romanov Riches: Russian Writers and Artists Under the Tsars?
    • ;
    • Schwarze Kleider (German Edition).

    Mix all ingredients together and stir until the mixture congeals. Hydroquinone Cream and GelHydroquinone is 1,4-benzenediol. Charge ascorbyl palmitate and butylated hydroxy anisole in a suitable vessel and dis- 5. Add step 4 into step 2 while mixing to minimize solve in oleyl alcohol, SDA anhydrous alcohol, air entrapment. Add item 16 and mix well; add item 17 and2. Stir to dis- petrolatum, behenyl erucate, and cetyl alcohol solve. Add step 2 to step 1 in a homogenizer, and then2. Add tocopherol to above just before adding the during homogenization add step 4 and also add rest of the ingredients see below.

    Handbook of Pharmaceutical Manufacturing Formulations: Semisolid Products (Volume 4 of 6)

    Add items 18 and 19 and mix well. Add and disperse item Charge items 2—7 one by one and mix for 20 4. Add step 3 into step 2. Homogenize at speed I under vacuum. Dissolve item 4 in items 5 and 6. Maintain cool until the air bubbles escape. Add solution of item 5. Dissolve item 4 and cool. Dissolve items 4 and 5 and cool.

    Add solution of item 6. Add and dissolve item 8 in item 11 separately and add to step 5. Charge and mix items 11, 2, and 3 in a stainless steel vessel. Charge item 2 and in a separate vessel, dissolve, and add to step 7. Add and dissolve item 5 in step 1 by stirring. Add and dissolve item 6 in step 1 after passing 8. Charge items 9 and 10 in a separate container, mix, and transfer to step 8. Mix and homogenize suspension.

    Mix thoroughly, transfer to storage vessel, and5. Dissolve item 7 in item 11 and add to step 4. Chemically, imiquimod is 1- 2-white oil-in-water vanishing-cream base consisting of methylpropyl -1H-imidazo[4,5-c]quinolinamine. Imiqui-isostearic acid, cetyl alcohol, stearyl alcohol, white pret- mod has a molecular formula of C14H16N4 and a molecularrolatum, polysorbate 60, sorbitan monostearate, glycerin, weight of Cool to room temperature.

    Add and mix item 5 and cool to form a yellow gel. Dissolve item 4 with stirring for about 30 min- 4. Addition of item 5 enhances chemical stability of item 1. Dissolve item 4 with stirring for about 30 min- utes. Indomethacin SuppositoriesThe suppositories for rectal use contain 50 mg of glycol , and sodium chloride. Indomethacin is a non-indomethacin and the following inactive ingredients: Charge indomethacin slowly to hopper while1.

    Charge the polyethylene glycol , polyeth- ylene glycol Stir until completely dissolved. A clear Becomix machine. Charge edetic acid to the hopper and stir for Stir the mixture for 30 minutes, maintaining the3. Prepare solution of items 5 and 6. Add, with milling, the remaining ingredients1. Cool with eted kettle. Transfer to a homogenizer mill. Add, with mixing, the fragrance and alcohol. Slowly add, with high-shear agitation, the Package immediately. Carbosil and the microtitanium dioxide.

    All instructor resources are now available on our Instructor Hub. The student resources previously accessed via GarlandScience. What are VitalSource eBooks?

    Handbook of Pharmaceutical Manufacturing Formulations: Sterile Products

    No other area of regulatory compliance receives more attention and scrutiny by regulatory authorities than the regulation of sterile products, for obvious reasons. With the increasing number of potent products, particularly the new line of small protein products, joining the long list of proven sterile products, the technology of manufacturing sterile products has evolved into a very sophisticated industry.

    Learn More about VitalSource Bookshelf. CPD consists of any educational activity which helps to maintain and develop knowledge, problem-solving, and technical skills with the aim to provide better health care through higher standards. It could be through conference attendance, group discussion or directed reading to name just a few examples. Prashant marked it as to-read Jul 28, Talat marked it as to-read Aug 20, Nurarifatulhasanah marked it as to-read Aug 21, Ekram marked it as to-read Nov 07, Alamanda marked it as to-read Nov 26, Abdu Robbi marked it as to-read Mar 01, M Hafizh marked it as to-read Mar 04, Maes Septiwi marked it as to-read Mar 08, Sefriesta A marked it as to-read Mar 08, Ananta Agung marked it as to-read Apr 07, Reham Ibrahem added it Apr 10, Venny Herman marked it as to-read May 18, Michael Shulman marked it as to-read Mar 29, Chiraphong Auttamalang marked it as to-read Nov 16, Nikki Vista marked it as to-read Feb 24,