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Because of well-tolerability and acceptable adverse effects, ER agonists might be considered as therapeutic agents for the patients with glial tumors. Original Research Breast Pathology. The International Ki67 in Breast Cancer Working Group suggests the counting of or cancer cells, which is a time-consuming process. Therefore, novel methods, Therefore, novel methods, such as the Eye method and stepwise counting strategy, are proposed to facilitate measurement. Methods:Immunohistochemical staining of Ki67 was performed on hormone-receptor-positive invasive ductal carcinoma specimens.
Finally, by using a dynamic process with rejection regions, Ki67 was defined so if the estimate belonged to the upper or lower rejection region, the Ki67 status had been determined and if the rejection region could not be reached after counting the maximum number of tumor cells, the specimen was regarded as equivocal stepwise counting strategy.
Both methods are much faster and simpler than evaluation of Ki67LI and are also reliable. Regarding the gray zone in both methods, further improvements in the methodology, as well as more analytical studies, are needed.
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Original Research Immunology and Serology. We supposed that the We supposed that the disruption of semen or spermatozoa might be responsible for the dysfunction of the immune system in women with URSA. Semen and spermatozoa as antigens induce female reproductive tract FRT immunity. This stimulated immunity is necessary for pregnancy occurrence.
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The disruption of semen or spermatozoa can be a result of altering a variety of surface molecules on spermatozoa, especially polymorphic human leukocyte antigen HLA molecules or antigens. Therefore, this paper aims to assess this relation. After purification of normal spermatozoa, the HLA class I and II expressions were evaluated by flow cytometry methods.
Original Research Biochemistry. Methods:In a case-control study, we investigated AV patients and healthy individuals aged The serum level of IGF-1 was The serum level of insulin in female patients was significantly higher than controls. The HOMA was 3. Significantly higher levels of fasting blood sugar FBS , total cholesterol, and low-density lipoprotein-cholesterol LDL-C were detected in female patients than controls.
However, the level of estradiol was significantly lower in female patients than in controls. Original Research Molecular Pathology. Several studies have given the evidence for and against viral cofactors in the pathogenesis of Idiopathic pulmonary fibrosis. In this study The HHV-8 gene was identified in 3 out of 29 As high iso-antibody production is closely associated with different immune reactions, a survey on the different As high iso-antibody production is closely associated with different immune reactions, a survey on the different immune response of dangerous O donors can lead to understanding their immune response profile.
Objectives were to assess different immune responses in dangerous O cases. Moreover, after using PHA and LPS, gamma globulins and lymphocyte proliferation were significantly higher in high titer cases. Moreover, high titer donors are dangerous for transfusion medicine. This pilot study showed differences in immune responses between HR and LR O blood donors for the first time. So, other aspects of the immune system such as genetic differences can be surveyed. Case Reports Uropathology. It represents a diagnostic challenge as it can simulate poorly differentiated adenocarcinoma and various mesenchymal neoplasms of prostate.
We report a case of prostate Read More Solitary fibrous tumor SFT of prostate is an unusual type of mesenchymal neoplasm that can elicit a benign or malignant phenotype. We report a case of prostate SFT in a year-old patient, which was clinically misdiagnosed as nodular hyperplasia of prostate with cystitis. However, on follow-up, he was not relieved by the designated treatment. Furthermore, he complained of exacerbation of symptoms and consequently, had to undergo open prostatectomy.
Additionally, we have discussed the histological mimics of SFT and the diagnostic and prognostic importance of IHC while evaluating such lesions. Case Reports Neuropathology.
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Although neonatal sacrococcygeal teratoma has been frequently reported, its occurrence in older age is not common. In this study, we report a rare case Read More Teratoma is a type of multipotential cell tumor, which includes a mixture of two or three germinal layers of ectodermis, endodermis, and mesodermis. In this study, we report a rare case of spinal intradural mature cystic teratoma in a year-old male, emphasizing on considering this unusual condition in differential diagnosis of spinal cord cystic tumors. Case Reports Gynecologic Pathology.
A 59 year old woman, initially presented to Kosar teaching hospital gynecology clinic April with a single, well defined, scaly, white ulcerated mass, 2 cm in diameter on right minor labia, but other examinations were normal. She had no urinary or gastrointestinal symptoms. She underwent radical vulvectomy. No evidence of disease recurrence was noted after 16 months follow up. Participant consent was obtained before patient was enrolled in this study.
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There are lot of diseases that involve genitalia and lead to vulvar lesions. Additionally, the clinical presentation as a vulvar mass was found unusual. Therefore, we report the case to sensitize gynecologists and pathologists for uncommon pathologies and their manifestations in vulva. Case Reports Diagnostic Pathology.
Due to its prominent stromal alternations, carotid body paraganglioma is a great emulator of other neoplasms in the head and neck region especially in metastatic tumors and its definite diagnosis is a great challenge. Read More Carotid body paraganglioma is a neuroendocrine neoplasm of the mandibular region. To the best of our knowledge, the most frequently reported variant is sclerosing and paraganglioma with a prominent lymphoplasmacytic infiltration is extremely rare. We report a rare case of a carotid body lymphoplasmacytic paraganglioma presented as a single asymptomatic mass of the right mandibular region in a year-old woman.
In order to exclude other possibilities, the use of immunohistochemistry is essential which shows a strong positive immunoreaction for chromogranin and synaptophysin. Surgical resection is the treatment of choice which is replaced with radiotherapy in contraindications.
Overall, the tumor has a favorable clinical outcome. Any subtypes of RCC can undergo sarcomatoid differentiation, but heterologous differentiation in sarcomatoid area is very rare in RCC. Here ayear male is Here ayear male is presented with hematuria and palpable mass.
Clinicoradiologically, RCC was considered and left radical nephrectomy was performed. A well-circumscribed renal mass located in the upper pole of the left kidney with variegation and extensive areas of bony hard calcification noted, was reported as CRCC with sarcomatoid differentiation containing heterologous component. CRCC subtype has good prognosis but show dismal prognosis when associated with sarcomatous differentiation. We found11 cases of sarcomatoid CRCC containing heterologous elements reported in indexed English literature.
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The extensive sampling of the tumor is needed. We report a very rare case of CRCC with sarcomatoid differentiation containing heterologous elements. The objective of this cross-sectional study was to examine the prevalence of HPV genotypes in 10, Iranian The objective of this cross-sectional study was to examine the prevalence of HPV genotypes in 10, Iranian male and female population, according to their age.
Methods: Samples were collected from the penile and anal sites of male subjects and the vagina and cervix of female subjects in a time period between and In hurriedly uttered apostrophes addressed to Apollo seven opening lines of this section span over the length of 16 semibreves, and the remaining six over 21 semibreves the Singer conveys his anxiety to quench the flame of his passionate love in the merry terror of the nocturnal silence.
Only once in the whole monologue. The sonority does not alter here. As the first part draws to an end with a triad based on the final of the mode G-Mixolydian bar , the same chord is resounding. In the entire Orfeos monologue the only rests that appear in the vocal part apart from the one after the exclamation Antri are those that separate both sections.
It does not mean, however, that Caccini did not specify lines. He did so by finishing lines with longer-value notes, i. Still, the way of articulating the text in the whole monologue is uniform. Next to the repetition of the same phrase Bella Madre dAmor with the figure gradatio, also a fourth up, Caccini stressed the emotional load of the word twice more: in line 20 it is the word venga and in line 22, the phrase A temprar tante fiamme, always accompanied with.
The monologue deploys cantus durus and nearly exclusively the accidental frii. The predominant mode is G-Mixolydian: in basso continuo of both parts the note G reappears very frequently, occasionally sustained over two semibreves. At some points of the first section basso continuo becomes more active than in a stricter form of recitative. At the end of this section the composer applies a clausula founded on note A, which might be seen as an excursion to the mode a-Aeolian.
Apart from infrequent transitory dissonances this section is determined by the diatonic arrangement. At this point, the composer shapes the melody in an unorthodox way. If compared with other recitatives that belong to the part of Orfeo, this one sounds more tuneful, which stems from using a smaller number of repetitions they account for merely a third of all melodic intervals and unusual exposition of progressions.
The monologue deploys cantus durus and nearly exclusively the accidental friii. Its governing mode is G-Mixo lydian, but its predominance is much more evident than in Peris work: the note G occurs in basso continuo as frequently as in Peris opera, even in the form of several semibreves in close succession; at two points there are detours to the mode a-Aeolian. With the exception of transitory dissonances the composer deploys a seventh chord four times marked with figures. On the one hand Caccini formed the melody with fewer repetitions in favour of seconds and larger intervalsiv. On the other hand, repetitions are of lesser importance in the structuring of all of Orfeos recitatives, and his first appearance does not stand out as different from others even by other.
The change of mood in the second part of the monologue is reflected with an even smoother melody: its tunefulness is magnified thanks to the application of a melodic figure used ten times typical of Caccinis musicv comprised of a third or fourth down and a return to the initial note. The smoothness of flow becomes even more enhanced as the lines are not split with rests. Peri, in turn, only used two semibreves as a form of closing the last line of Orfeos recitative and only five times did he employ one semibreve within the recitative.
On stage comes the Messenger who announces Euridices death. Orfeo: [1] E per te, Tirsi mio, liete e ridenti [2] Sempre le notti e i d rimeni il sole. Dafne Nunzia Messaggera : [3] Lassa! Che di spavento, e di pietate [4] Gelami il cor nel seno! For greater emphasis of the contrasting moods, the composer modified the text by Rinuccini and rearranged the order of the words so that Dafnes cry of despair Lassa clashes directly with the cheerful word ridentii as proclaimed by Orfeo.