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The Global Initiative for Asthma is a medical guidelines organisation which works with public health officials and health care professionals globally to reduce asthma prevalence, morbidity, and mortality.
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- Gina McCarthy
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Give today. Faculty Gina Razidlo, Ph. Location Rochester, Minnesota Contact Razidlo. Gina mayo. Focus areas Cytoskeletal signaling and metastasis.
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The actin cytoskeleton provides the structural and mechanical framework for cell migration and invasion. Razidlo and colleagues study how novel regulators of the actin cytoskeleton control pro-invasive signaling pathways and the structural changes that drive pancreatic cancer cell metastasis.
Signals from the tumor microenvironment that promote metastasis. The complex tumor microenvironment provides cues that signal to tumor cells and promote tumor growth and metastasis. Chronic inflammation is associated with increased cancer risk and metastasis.
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Razidlo is investigating how specific inflammatory signals make tumor cells more invasive, and how cancer cells themselves contribute to the inflammatory environment in tumors. Metabolic changes that fuel metastasis. Invasive migration is a highly energy-intensive process and requires generation of sufficient energy to power cytoskeletal and membrane remodeling. In pancreatic cancer, the oncogene KRas contributes to a metabolic rewiring of tumor cells.
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Razidlo and colleagues are investigating the mechanisms by which tumor cells alter their metabolism to drive metastasis, and how KRas activation couples the tumor environment to the activation of dynamic cytoskeletal changes. Significance to patient care Novel strategies for cancer treatment are required to improve patient outcomes. Advertising Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission.
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Home | Global database on the Implementation of Nutrition Action (GINA)
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