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PageSpeed Score Not Applicable. Hosted IP Address: Hosted Country: ID. Location Latitude: Location Longitude: Page Title of sopiyudin-store. Pakar Statistik Indonesia. Page Resources Breakdown. Homepage Links Analysis. Osman Kids - null - osmankids. Yubistore - Mallnya Pebisnis Indonesia - store. Crayon Kids Batik - crayonkidsbatik. Http-Version : 1. The subjects were followed for 6 months to see the emergence of AD.

The diagnosis was based on Hanifin Rajka criteria. Exclusive breast feeding for the first 6 months as recommended by Indonesian Ministry of Health with the introduction of solid foods postponed to after the end of the sixth month was recommended. The total sample population of this study was subjects. The correlation between the dependent and independent variables was done by bivariate analysis followed by logistic multivariate analysis using SPSS There were subjects who fulfilled the eligibility criteria; of these, could be followed up until 6 months after birth.

Subjects' characteristics are shown on Table 1.

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Only a minority of children 2. Table 2 shows 37 subjects with AD that occurred in their first 6 months of life; Most subjects had AD first appearing in the first month. The bivariate correlation between some independent variables with incidence of AD is shown in Table 3. This study found that From From non-exclusive breastfeeding subjects that consisted of ETS: environmental tobacco smoke. In this study, Among the other From the AD subjects, The increasing of IL-5 is inconsistent with increasing IgE.

However, there was no significant association. The relationship between several variables towards the occurrence of atopic dermatitis AD in 37 cases of AD and 51 control cases on the case control design. According to the hygiene theory, the incidence of AD in Jakarta must be lower than incidence of AD in Western countries because the incidence and prevalence of infectious disease are still high.

However, it has changed since infectious disease rates have decreased and pollution has increased in Jakarta. Of the subjects with AD, In most subjects, AD appeared in the first month, similar to the incidence of AD in a study performed in England [ 1 ].

The result of this study strongly supports the importance of early allergic detection as an early screening tool to enable early prevention of allergic disease. Ngamphaiboon et al. From their study, Most of the allergy symptoms appeared in the first year of life All the subjects with a score of 1 had a significant correlation with the manifestation of allergy disease with OR 2.

The score that could be used for screening of the high-risk infant was more than 2 with Eller et al.

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Boys had earlier onset of AD than girls. Our study showed no significant differences between males and females. This may be explaind by the fact that both boys and girls live in the same indoor environment in early life. This study showed no significant correlation between hyperallergenic food consumption during pregnancy with the incidence of AD. The previous study showed that the fetus was able to respond against food and other allergens. Sometimes, food-specific IgE can be found [ 10 ], in addition to a T cell response against cow's milk protein, eggs, and aero allergens in the newborn baby [ 11 ].

Our study results support the American Academy of Pediatrics recommendations and European guidelines which do not recommend maternal avoidance of hyperallergenic foods during pregnancy. Meta analysis studies have shown that there was no benefit of maternal avoidance during pregnancy in preventing the occurrence of allergy in the fetus in later life [ 12 ]. These findings may give the impression that breast milk is a causative agent of AD. There are some possible explanations.

Since the important factor of AD pathogenesis is the skin's barrier defect, breastfeeding for a month is not enough to protect babies against allergic disease; however, breastfeeding may give protection in the gut barrier like in food allergy. Secondly, breastfeeding might be the cause of AD not because of the breast milk itself, but due to hyperallergenic food intake from the mother or the lack of anti-allergy components in breast milk which were not explored in this study. Out of This difference statistically seems to be a causative factor regardless of other confounding factors.

The difference in AD incidence in subjects exposed and unexposed to ETS was not statistically significant. Mills et al. Therefore, ETS avoidance is very important during pregnancy for early allergy prevention [ 14 ].

The increasing IL-5 level is inconsistent with increasing IgE. The increasing IL-5 distribution in the group with high total IgE levels can be explained by the fact that the production of total IgE by B cells is influenced by the activity of Th2 in this case IL The question that might arise is whether the increase of IgE besides allergy-related factors could also be cause by helminthic or other parasitic infestations of the mother.

Ustun et al. Such an infestation may be due to parasitic infestation in the subjects; however, this possibility was not explored in this study. AD mostly appeared by 1 month of age, when the possibility of allergen sensitization was still low. This could occur due to staphylococcal colonization, which starts from birth. In conclusion, this study showed that the role of influence factors that have been observed with the occurence of AD in the first 6 months of age were not significant. It means that these factors were not important, but still other factors may have correlation with the occurence of AD in the first 6 months of age.

The most important factor in AD is the skin barrier defect due to the fillagrin gene mutation. The genetic factor needs further study. We would like to thank Sopiyudin Dahlan M.

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We also thank all the parents for their participation in this study. National Center for Biotechnology Information , U. Journal List Asia Pac Allergy v. Asia Pac Allergy.

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Published online Jul Find articles by Zakiudin Munasir. Find articles by Sudigdo Sastroasmoro. Find articles by Samsuridjal Djauzi. Find articles by Sarwono Waspadji. Find articles by Wahyuning Ramelan. Find articles by Asril Aminullah. Find articles by Retno Widowati. Find articles by Alida Roswita Harahap. Find articles by Anang Endaryanto. Find articles by Iskandar Wahidiyat. Author information Article notes Copyright and License information Disclaimer. Corresponding author. Correspondence: Zakiudin Munasir.