Early Days of Molecular Biology in the California Institute of Technology (Annual Review of Biophysics and Biophysical Chemistry Book 15) - Kindle edition by.
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Clemons, Hoelz, Shan and various guest lecturers subject to change each year. Kinetics, Energetics, and Mechanisms. Discussion of the energetic principles and molecular mechanisms that underlie enzyme's catalytic proficiency and exquisite specificity. Principles of allosteric regulation, selectivity, enzyme evolution, and computational enzyme design. A course that includes a seminar on selected topics from outside faculty on recent advances in biochemistry. Students will participate in the seminar along with a formal discussion section with visiting faculty.
Students will meet with the Biochemistry seminar speaker in the discussion section for an hour, and then attend the Biochemistry seminar at 4 p. BMB Seminars take place times per month usually on Thursdays. Osheroff BS studied the superfluid nature of helium Donald Knuth PhD , the "father" of the analysis of algorithms , wrote The Art of Computer Programming and created the TeX computer typesetting system, which is commonly used in the scientific community. Narendra Karmarkar MS is known for the interior point method, a polynomial algorithm for linear programming known as Karmarkar's algorithm.
Other alumni have turned their gaze to the universe. Astronaut and later, United States Senator Harrison Schmitt BS was the only geologist to have ever walked on the surface of the moon. This ultimately resulted in the publication of the Abell Catalogue of Clusters of Galaxies, the definitive work in the field. Undergraduate alumni founded, or co-founded, companies such as LCD manufacturer Varitronix, [] Hotmail , [] Compaq , [] and MathWorks which created Matlab , [] while graduate students founded, or co-founded, companies such as Intel , [] TRW , [] and the non-profit educational organization, the Exploratorium.
His success with that company enabled him to provide seed funding for William Shockley BS , who had co-invented semiconductor transistors and wanted to commercialize them. Among the " traitorous eight " was Gordon E. Moore PhD , who later left Fairchild to co-found Intel. Other offspring companies of Fairchild Semiconductor include National Semiconductor and Advanced Micro Devices , which in turn spawned more technology companies in the area.
Shockley's decision to use silicon — instead of germanium — as the semiconductor material, coupled with the abundance of silicon semiconductor related companies in the area, gave rise to the term " Silicon Valley " [] to describe that geographic region surrounding Palo Alto. Caltech alumni also held public offices, with Mustafa A. Nobel laureate Douglas D. Osheroff , BS Turing Award laureate Fernando J. Abushagur , PhD Gordon Moore , PhD , co-founder of Intel.
Benoit Mandelbrot , MS , Engineering , father of fractal geometry , namesake of the Mandelbrot set. Stanislav Smirnov , PhD , Fields Medal winner for his work on the mathematical foundations of statistical physics , particularly finite lattice models. Nobel laureate Eric Betzig , BS , known for his work on fluorescence microscopy and photoactivated localization microscopy. Over the years Caltech has actively promoted the commercialization of technologies developed within its walls.
Caltech has appeared in many works of popular culture, both as itself and in disguised form.
As with MIT , a Caltech reference is often used to establish a character's high level of intelligence or a technical background; for example, in the novel Contact by Carl Sagan , Eleanor Arroway holds a Ph. Caltech is also the inspiration, and frequent film location, for the California Institute of Science of Numb3rs. In nonfiction, two documentaries examine aspects of Caltech: Curious , its researchers, [] [] and Quantum Hoops , its men's basketball team.
Given its Los Angeles-area location, the grounds of the Institute are often host to short scenes in movies and television. From Wikipedia, the free encyclopedia. For the Texas Instruments calculator, see Cal Tech calculator. Seal of the California Institute of Technology [1]. Campus of the California Institute of Technology. List of California Institute of Technology trustees.
California Institute of Technology
House System at the California Institute of Technology. List of California Institute of Technology people. Nobel laureate Vernon Smith , BS California Institute of Technology. Retrieved April 16, Retrieved December 26, Retrieved January 2, Retrieved January 19, The Institute is also occasionally referred to as "CIT", most notably in its alma mater , but this is uncommon.
Times Higher Education Rankings. Archived from the original on American Association of Universities. Retrieved May 29, Caltech Office of Marketing and Communications. Retrieved March 8, Archived from the original PDF on May 25, Retrieved May 12, Where to educate, A guide to the best private schools, higher institutions of learning, etc.
Retrieved August 17, Board of Trustees, California Institute of Technology. A History of the California Institute of Technology. Archived from the original PDF on April 9, Retrieved May 28, California Enters the s. Retrieved June 18, Retrieved September 29, Retrieved March 19, Retrieved September 26, Retrieved August 12, Archived from the original PDF on July 19, Archived from the original on November 9, Retrieved January 16, Archived from the original PDF on July 17, Retrieved February 19, Retrieved September 16, Caltech facility combines astronomy, astrophysics".
Retrieved July 7, Retrieved October 22, The Chronicle of Higher Education. Archived from the original on June 7, Retrieved May 30, Archived from the original PDF on August 25, Retrieved August 29, Retrieved November 23, Retrieved 25 July Retrieved September 21, Retrieved October 25, News Best Grad School Rankings". Retrieved 6 June News Best Global University Rankings". Retrieved 8 July Carnegie Foundation for the Advancement of Teaching.
Western Association of Schools and Colleges. Retrieved May 17, Retrieved January 21, Archived from the original on September 11, Retrieved September 9, Retrieved December 17, News Best Colleges Rankings". Caltech Graduate Studies Office. Retrieved October 15, The Quarterly Journal of Economics. Retrieved August 22, Archived from the original on May 10, Archived from the original on February 5, Caltech Office of the Registrar. Archived from the original on July 17, Retrieved December 15, Archived from the original PDF on June 28, Archived from the original on June 6, Retrieved June 1, Archived from the original on May 27, Archived from the original PDF on October 11, Retrieved 31 July Archived from the original on April 6, Archived from the original on November 2, Archived from the original on October 21, Archived from the original PDF on January 10, Archived from the original on May 12, Retrieved October 23, Archived from the original PDF on June 6, Principles of nuclear energy production: Satisfies the menu requirement of the Caltech core curriculum.
Fundamental Techniques of Experimental Chemistry. Introduces the basic principles and techniques of synthesis and analysis and develops the laboratory skills and precision that are fundamental to experimental chemistry. Freshmen who have gained advanced placement into Ch 41 or Ch 21, or who are enrolled in Ch 10, are encouraged to take Ch 3 a in the fall term. Experimental Methods in Solar Energy Conversion. Introduces concepts and laboratory methods in chemistry and materials science centered on the theme of solar energy conversion and storage.
Students will perform experiments involving optical spectroscopy, electrochemistry, laser spectroscopy, photochemistry, and photoelectrochemistry, culminating in the construction and testing of dye-sensitized solar cells. Synthesis and Analysis of Organic and Inorganic Compounds. Introduction to methods of synthesis, separation, purification, and characterization used routinely in chemical research laboratories.
Ch 4 a focuses on the synthesis and analysis of organic molecules; Ch 4 b focuses on the synthesis and analysis of inorganic and organometallic molecules. Ch 4 a, second term; Ch 4 b, third term. Advanced Techniques of Synthesis and Analysis. Ch 5 a 12 units , second term: Ch 5 b 12 units , first term. Specific experiments may change from year to year.
Experiments illustrating the multistep syntheses of natural products Ch 5 a , coordination complexes, and organometallic complexes Ch 5 b will be included. Methodology will include advanced techniques of synthesis and instrumental characterization. Terms may be taken independently. Part b not offered Physical and Biophysical Chemistry Laboratory. Introduction to modern physical methods in chemistry and biology. Techniques include laser spectroscopy, microwave spectroscopy, electron spin resonance, nuclear magnetic resonance, mass spectrometry, FT-IR, fluorescence, scanning probe microscopies, and UHV surface methods.
The two terms can be taken in any order. Advanced Experimental Methods in Bioorganic Chemistry. This advanced laboratory course will provide experience in powerful contemporary methods used in chemical biology, including polypeptide synthesis and the selective labeling and imaging of glycoproteins in cells. Experiments will address amino acid protecting group strategies, biopolymer assembly and isolation, and product characterization.
A strong emphasis will be placed on understanding the chemical basis underlying the successful utilization of these procedures. In addition, experiments to demonstrate the application of commercially available enzymes for useful synthetic organic transformations will be illustrated. Open to non-pre-medical students, as space allows. Introduction to methods of extraction, synthesis, separation and purification, and spectroscopic characterization of Aspirin, Tylenol, and medical test strips. Chemical Synthesis and Characterization for Chemical Engineering.
Instruction in synthesis, separation, purification, and physical and spectroscopic characterization procedures of model organic and organometallic compounds. Specific emphasis will be focused on following the scientific method in the study of model organic and inorganic materials. Enrollment priority given to chemical engineering majors. Ch 10 ab is a weekly seminar by a member of the chemistry department on a topic of current research; the topic will be presented at an informal, introductory level. The other weekly session will acquaint students with the laboratory techniques and instrumentation used on the research topics.
Ch 10 c is a research-oriented laboratory course, which will be supervised by a chemistry faculty member. Weekly class meetings will provide a forum for participants to discuss their research projects. Introduction to Chemical Engineering. A series of weekly seminars given by chemical engineering faculty or an outside speaker, on a topic of current research. Topics will be presented at an informal, introductory level.
Chemical Equilibrium and Analysis. This course will cover acid-base equilibria, complex ion formation, chelation, oxidation-reduction reactions, and partitioning equilibria. These topics will serve as the basis for introducing separation techniques such is gas and liquid chromatography and the hyphenated techniques associated with them GC-MS, LC-MS, etc. Laboratory activities will be integrated with the course topics.
Chemical Equilibrium and Analysis Laboratory. Laboratory experiments are used to illustrate modern instrumental techniques that are currently employed in industrial and academic research. Emphasis is on determinations of chemical composition, measurement of equilibrium constants, evaluation of rates of chemical reactions, and trace-metal analysis. Introduction to Chemical Engineering Computation. Introduction to the solution of engineering problems through the use of the computer.
Elementary programming in Matlab is taught, and applied to solving chemical engineering problems in data analysis, process simulation, and optimization. No previous knowledge of computer programming is assumed. Atomic and molecular quantum mechanics, spectroscopy, thermodynamics, statistical mechanics, and chemical kinetics. Chan a , Blake b , Beauchamp c.
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Introduction to Biophysical Chemistry: Develops the basic principles of the interaction of light with matter, including spectroscopic and scattering methods of macromolecular structure determination, with emphasis on biochemical and biophysical applications. Develops the basic principles of solution thermodynamics, transport processes, and reaction kinetics, with emphasis on biochemical and biophysical applications.
The synthesis, structure, and mechanisms of reactions of organic compounds. Dougherty a , Hsieh-Wilson b , Fu c. Introduction to mass transfer. A comprehensive treatment of classical thermodynamics with engineering and chemical applications. First and second laws. Applications to closed and open systems. Properties of real fluids.
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Power generation and refrigeration cycles. Multicomponent systems, excess properties, fugacities, activity coefficients, and models of nonideal solutions. Phase and chemical reaction equilibria. Units in accordance with work accomplished: Experimental and theoretical research requiring a report containing an appropriate description of the research work.
Research in chemical engineering offered as an elective in any term other than in the senior year. Independent Reading in Chemistry. Occasional advanced work involving reading assignments and a report on special topics. No more than 12 units in Ch 81 may be used as electives in the chemistry option. Ch is taken only by students pursuing a joint B. At the end of the third term, students enrolled in Ch 82 will present a thesis of approximately 20 pages excluding figures and references to the mentor and the Chemistry Curriculum and Undergraduate Studies Committee.
The thesis must be approved by both the research mentor and the CUSC. Students enrolled in Ch will present a Masters Thesis, as described in requirements for the Masters degree. An oral thesis defense will be arranged by the CUSC in the third term for all enrollees.
Training in the techniques of oral presentation of chemical and biochemical topics. Practice in the effective organization and delivery of technical reports before groups. Strong oral presentation is an essential skill for successful job interviews and career advancement. A research project carried out under the direction of a chemical engineering faculty member.
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The project must contain a significant design component. Students must submit a proposal outlining the proposed project, and clearly identifying its design component to the faculty mentor for the thesis and the chemical engineering option representative, by the beginning of the first term of the thesis for review and approval. A grade will not be assigned prior to completion of the thesis, which normally takes two terms.
A P grade will be given for the first term and then changed to the appropriate letter grade at the end of the course.
Training in the writing of scientific research papers for chemists and chemical engineers. Fulfills the Institute scientific writing requirement. Small group study and discussion on special areas of chemistry, chemical engineering, molecular biology, or biophysics. Instructors drawn from advanced graduate students and postdoctoral staff will lead weekly tutorial sessions and assign short homework assignments, readings, or discussions.
Tutorials to be arranged with instructors before registration. Gray, Okumura, Stoltz, Tirrell. Elements of chemical kinetics and chemically reacting systems. Homogeneous and heterogeneous catalysis. Introduction to Inorganic Chemistry.
Structure and bonding of inorganic species with special emphasis on spectroscopy, ligand substitution processes, oxidation-reduction reactions, organometallic and biological inorganic chemistry. A rigorous development of the basic differential equations of conservation of momentum, energy, and mass in fluid systems.
Solution of problems involving fluid flow, heat transfer, and mass transfer. Dynamics and Control of Chemical Systems. Analysis of linear dynamic systems. Stability of closed-loop control systems.
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Root locus, Frequency response, and Nyquist analysis. Feedforward, cascade, and multivariable control systems. Lectures and recitation introducing the molecular basis of life processes, with emphasis on the structure and function of proteins. Topics will include the derivation of protein structure from the information inherent in a genome, biological catalysis, the intermediary metabolism that provides energy to an organism, and the use of DNA manipulations, cloning, and expression of proteins in foreign hosts to study protein structure and function.
Biochemistry of Gene Expression.