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See details for additional description. Skip to main content. We're sorry, something went wrong. Please try again. Castle , Paperback Be the first to write a review. About this product. Stock photo.

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Brand new: lowest price The lowest-priced brand-new, unused, unopened, undamaged item in its original packaging where packaging is applicable. Books will be free of page markings. See details. William Hazen Gates Genetic studies of rabbits and rats, by W. Castle Studies of heredity in rabbits, rats and mice, by W. Genetics and eugenics, a text-book for students of biology and a reference book for animal and plant breeders, by W.

Studies of inheritance in Guineapigs and rats, by W. Castle and Sewall Wright Piebald rats and selection, an experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crosses Reversion in Guinea-pigs and its explanation, by W. Experimental studies of the inheritance of color in mice, by C.

Little Castle was married in to Clara Sears Bosworth, who remained his constant companion until her death in The vitality that Castle brought to his work was somewhat masked by an external appearance of reserve and formality, yet he was strongly liked by his students and respected by his colleagues. As a farm boy, he collected wild flowers and learned to graft trees and to reconstruct skeletons of animals.

At Denison, Clarence J. Academic emphasis at Denison was on classics, however, and Castle majored in Latin.

After graduation he taught classics at Ottawa University, Ottawa, Kansas, from to In the fall of that year he entered Harvard University to pursue further his interests in natural history. He received his Ph. This work was directed toward the elucidation of certain disputed questions concerning the mode of origin of the primary germ layers of tunicates.

guinea pig | Diet, Life Span, & Facts | Britannica

Carefully and methodically tracing the embryonic state of every cell from first cleavage through late gastrula. Castle took issue with the prevailing view of the origin of the chordate mesoderm. He concluded correctly that the mesoderm in Ciona and other primitive chordates originates from pouches in the infolded endoderm of the gastrula, in a manner similar to that in the echinoderms.

Ciona is a hermaphrodite in which individuals are self-sterile i. In the course of his studies Castle also discovered that self-fertilization is prevented not, as had been supposed, by ripening of sperm and eggs at different times but by physiological incompatibility between the gametes. This phenomenon had already been observed in certain flowering plants but never before in animals; Castle speculated that such a block to self-fertilization was probably chemical in nature.

Somewhat complex, his interpretation involved a subsidiary assumption of selective fertilization i.

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At the same time, however, Castle was carrying out a long series of experiments — on inbreeding and outbreeding in the fruit fly Drosophila. Castle was the first to use this organism for any extensive laboratory breeding experiments, and it was through his work that T. The first question was attacked in a series of breeding experiments with guinea pigs between and Castle showed that the inheritance of coat colors followed strictly Mendelian lines, a conclusion that was verified by the work of Bateson, Punnett, A.

Darbishire, Doncaster, C.

Heredity of Coat Characters in Guinea-Pigs and Rabbits by William E. Castle (2008, Paperback)

Hurst, and Cuenot on a variety of other organisms. Unlike William Bateson , however. Castle was by no means a complete convert to all the Mendelian assumptions. For example, Castle tended to answer the second question posed above in the negative.

He believed that it was possible for two contrasting genes in a heterozygote to affect or contaminate each other in such a way that neither gene expressed itself in the same manner in subsequent generations. Thus, as a corollary. Castle maintained that it was possible to produce permanent blends of contrasting characters, a conclusion that was somewhat substantiated by his studies of inheritance of mammalian coat colors. In Castle, with the expert surgical help of his co-worker J. Castle and Phillips transplanted the ovaries from a pure black guinea pig into a pure white guinea pig whose own ovaries had been removed.

The transplant took, and in three subsequent breedings the female produced only black offspring. Thus, the genetic composition of the ovaries was unaffected by their being in the body of a different genetic type. In June Hansford MacCurdy, along with Castle, completed a study of the inheritance of color patterns in rats. Hooded rats are white with a colored area darkly pigmented on the head and a narrow line down the back.

A hooded rat crossed with a wild rat produced all wild F 1.

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In the 2 F the ratio of wild to hooded was The hooded individuals, however, showed a much greater variability as a result of this cross. This suggested to MacCurdy and Castle that the recessive hooded gene was modified by existing in the hybrid along with genes for normal, wild pigmentation.

Using this variability, Castle, with MacCurdy and J.