Applications of Antisense Therapies to Restenosis (Perspectives in Antisense Science)

Series: Perspectives in Antisense Science (Book 3); Hardcover: pages; Publisher: Springer; edition (February 28, ); Language: English; ISBN-
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Ebook Applications Of Antisense Therapies To Restenosis

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Perspectives on antisense therapy for the prevention of restenosis. - Abstract - Europe PMC

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In addition, the charged phosphodiester internucleotide linkage is replaced by an uncharged phosphorothioate. The PMOs are resistant to serum nucleases found in serum and exhibit a high degree of specificity and efficacy in both in vitro and cell-free translation studies. In vivo studies in four different animal models of restenosis demonstrated significant reduction of myointimal response.

The combination of enhanced efficacy and greater specificity introduced by the PMO chemistry led us to re-examine the potential efficacy of a neutrally charged c-myc antisense approach for the prevention of restenosis. Clinical studies are underway to investigate safety and efficacy of local delivery of this latest generation of antisense to reduce restenosis after coronary stenting.

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