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- Thermoradiotherapy and Thermochemotherapy: Biology, Physiology, Physics: 1 (Medical Radiology)
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Nieuwe citaties van deze auteur. Nieuwe artikelen gerelateerd aan het onderzoek van deze auteur. Mijn profiel Mijn bibliotheek Statistieken Meldingen. Mijn eigen profiel maken Geciteerd door Alles weergeven Alles Sinds Citaties h-index 38 18 iindex 71 Radiotherapie Klinische Fysica Radiation Oncology. Artikelen 1—20 Meer weergeven. IMRT boost dose planning on dominant intraprostatic lesions: Accuracy in radiation field alignment in head and neck cancer: Quality assurance using portal imaging: Reirradiation of recurrent head and neck cancers: Together with its unsubstantial theory, unfortunately, this result correlates slightly with the clinical practice.
To use the in-vivo systems, due to the systemic and other physiological effects this case, the inaccuracy of the empirical dose is unfortunately always valid. The empirical dose-dependence was proven by the canine randomized trial only in low and high dose significance.
Thermoradiotherapy and Thermochemotherapy: Biology, Physiology, Physics: 1 (Medical Radiology)
We have theoretically deduced by very general conditions that the cell destruction reaction rate fulfils the Arrhenius-law. In accordance with this, we are going to show that under certain conditions the Separeto-Dewey empirical formula can be deduced from the Arrhenius-law. Let us start from the isothermal cell destruction of 43oC. Then, the number of destructed cells during t time will be as follows. Let us take another isothermal treatment of temperature T and examine the section of the same slope of Arrhenius-graph. Of course, it is quite complicated in the practice as the slope depends on the conditions of pre-treatment.
As the process is isothermal, we might define the same death rate for the other temperature: As this is a very small value, the applied approximation is good. The approximation is not so good if we compare two treatments for which the slope of Arrhenius-graph is different we should not forget that these in-vitro examinations have not got any in-vivo dynamics. This expression is formally corresponding with the equivalent treatment time derived from the empirical dose.
So if the energy taken to the activation and distortion is neglected, the energy- and empirical-doses are identical and the parameters have to fulfil the following condition:. This means that the present non-equilibrium thermodynamics describes well the given processes. Also it seems that the present energy dose is more general, it can consider the memory effects of the actual processes and with this fits better to the reality.
It is interesting to observe the changes caused by the different factors pH, low glucose level, thermo-tolerance: The slope of the lower section of Arrhenius-graph the section belonging to the higher temperature will be approximately identical with the slope of the section belonging to the lower temperature. The A proportionality factor changes in the equation In accordance with the above deduction, both effects influence the accuracy of the empirical formula Regarding the qualitative effect, the jump in the survival graph - which can be observed as a function of treatment time and shows significant deviations for the treatments of different temperatures [85] - will lessen.
Additional problem is that in the case of hyperthermia treatment the target temperature is obtained from the solution of Pennes-equation. In this case the temperature distribution is calculated numerically and from this we get the T 90 temperature and the CEM43oC T 90 dose. To verify the temperature the non-invasive MRI measurement is in use, [86] , [87] for what presenting the physiological effects e.
In consequence of the above, the form of the heat-conduction equation Pennes- or Pennes-like-equation affects the definition and the definability of the adequate dose. The original Pennes equation does not describe the reality well, does not consider the energy heat consumed by the cell-distortion processes. This cell-disruption however is the main goal of the entire process.
Due to the missing energy, the dose calculated from the Pennes equation is always higher than the reality. The difference between the temperatures calculated from the Pennes equation TP and the temperature derived from our present work could be calculated by perturbation theory as a simples approach. This could be accurate in the case, when the energy intake by the cell-disruption is much less than the overall energy absorption. Of course this is not an optimal treatment, when most of the energy is not expended to the desired job, but this could be a good approximation of the reality in most of the treatment cases.
Stopping at the first term of the perturbation approximation, the deviation of the real and the Pennes-calculated temperature is:. The difference between the results of the two approximations grows by the relative energy portion of the cellular distortion in the complete energy-intake.
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If we have a definite high temperature and the criteriais such a result then of course we pump the energy much higher than the distortion requests, the temperature in fact only the "non-directly-used" part of the energy-intake. The distinguishing between the "heatable" and "unheatable" patients in reality is the condition that the energy expending to the distortion has to be negligible, "heatable-patient" so the temperature could be the control parameter instead of the correct energy control. Starting by the definition point of the hyperthermia, we considered the energy intake of the cellular distortion during the treatment.
The present work proposes to consider the energy expended on the cellular destruction in the frame of the analogue reaction-kinetics. On this base we worked out the non-equilibrium thermodynamic theory of the hyperthermia processes. Results of the above considerations are the generalized Pennes equation and two reaction-equations one for the activation and one for cellular destruction. Based on the generalized Pennes equitation, we introduced the energy-dose which contains a clinically observable term, the memory effect, namely the effect of the irreversible changes depending on the time, which is characteristically longer or at least comparable with the treatment time.
We had shown that neglecting the distortion energy, memory effect the newly introduced energy-dose and the Separeto-Dewey empirical-dose are identical. This is a control of the new dose-calculation and at the same time shows the reality of the rigorous thermodynamic basis of the empirical-dose as well. By studying the differences between the energy- and empirical-doses, we established that they are near to each other if the energy intake is large enough to neglect the energy of the distortion or the distortion process is so immediate that its time is negligible compared to the treatment time.
Considering the definitive task of hyperthermia to destroy the malignant cells, the cell-disruption and the energy expended on this is mandatory in the process. In this regard, our present calculation is important to clarify the quality assurance and all the quality guidelines of oncological hyperthermia. Back to cited text no. Effect of hyperthermia on malignant cells in vivo. A review and a hypothesis. Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European Society for Hyperthermic Oncology.
Int J Hyperthermia ; Prospective randomized study of hyperthermia combined with chemoradiotherapy for esophageal carcinoma. J Surg Oncol ; A randomized clinical trial of hyperthermia and radiation versus radiation alone for superficially located cancers. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: A prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group. Phase III study of interstitial thermoradiotherapy compared with interstitial radiotherapy alone in the treatment of recurrent or persistent human tumors.
A prospectively controlled randomized study by the Radiation Therapy Group. Hyperthermia combined with chemotherapy - biological rationale, clinical application and treatment results. Hyperthermia in combined treatment of cancer. Those in gene therapy should pay closer attention to lessons learnt from hyperthermia. Lessons learned from hyperthermia. A future for hyperthermia in cancer treatment? Eur J Cancer ; Thermo-radiotherapy and thermo-chemotherapy, vol. Biology, Physiology and Physics. Analysis of tissue and arterial blood temperatures in the resting human forearm.
J Appl Physiol ;1: Non-invasive, in-vivo electrical impedance of EMT-6 tumors during hyperthermia: Correlation with morphology and tumour-growth delay. Changes in the non-invasive, in vivo electrical impedance of the xenograpfts during the necrotic cell-response sequence. Vaupel P, Kallinowski FP.
Blood flow, oxygen and nutrient supply and microenvironment of human tumors: Differential response of normal and tumor microcirculation to hyperthermia. Implication of blood-flow in hyperthermic treatment of tumors. Microvasculature and persfusion in normal tissues and tumors, thermoradiometry and thermochemotherapy. Action of Hyperthermia and Ionizing radiation on plasma membranes. Cancer therapy by hyperthermia and radiation. Correlation between cell killing effect and cell-membrane potential after heat treatment: Analysis using fluorescent dye and flow cytometry.
Will hyperthermia conquer the elusive hypoxic cell? Implications of heat effects on tumor and normal-tissue microcirculation. Biology, physiology and physics.
The colloid chemistry of protoplasm. Am J Physiol ; Membrane lipid composition and sensitivity to killing by hyperthermia, Procaine and Radiation. Biological Basis of Thermotherapy with special reference to Oncology. Biological basis of oncologic thermotherapy.
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Symp Soc Exp Biol ; Physiological aspects of heat and cold. Am Rev Physiol ; Hyperthermia and the membrane potential of erythrocyte membranes as studied by Raman Spectroscopy.
Effects before, during and after Gene activation. Hodgkin AL, Katz B. The effect of temperature on the electrical activity of the giant axon of the squid. The effect of hyperthermia induced tissue conductivity changes on electrical, impedance temperature mapping.
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Phys Med Biol ; Electric properties of tissues. Wiley Encyclopedia of Biomedical Engineering. John Wiley and Sons Inc: DNA polymerase activity in heat killing and hyperthermic radiosensation of mammalian cells as observed after fractioned heat treatments. Hyperthermy increase the phosporylation of deoxycytidine in the membrane phospholipid precursors and decrease its incorporation into DNA. Adv Exp Med Biol ; Dikomey E, Franzke J.
Int J Radiat Biol ; Heat inactivation of DNA-dependent protein kinase: Possible mechanism of hyperthermic radiosensitization. Heat shock proteins, thermotolorence and their relevance to clinical hyperthermia. Soti C, Csermely P.
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Molecular chaperones in the etiology and therapy of cancer. Unusual expression and localization of heat shock proteins in human tumor cells. Int J Cancer ; Constitutive expression of the heat shock protein 72kDa in human melanoma cells. Differenctial expression of heat shock proteins in pancreatic carcinoma. Punyiczki M, Fesus L. Heat shock and apoptosis: The two defense systems of the organisms may have overlapping molecular elements.
Ann NY Acad Sci ; Co-induction of HSP27 phosphorylation and drug resistance in Chinese hamster cells.
Int J Oncol ;1: Goodman R, Blank M. Spontaneous apoptosis and expression of cell-surface het-shock proteins in cultured EL-4 lymphoma cells. Regulation of the specific DNA binding function of p A new member of the HSP90 Family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. Mol Cell Biol ; Temperature monitoring and heating optimization in cancer hyperthermia. Prog Nat Sci ; Deng ZS, Liu J. Analytical study on bioheat transfer problems with spatial or transient heating on skin surface or inside biological bodies. A hybrid equation for simulation of perfused tissue during thermal treatment.
Int J Hyp ; Theoretical analysis of the thermal effects during in vivo tissue electroporation. Transient solution to the bioheat equation and optimization for magnetic fluid hyperthermia treatment. Application of the time-dependent Green's function and Fourier transforms to the solution of the bioheat equation. Pennes' paper revisited. J Appl Physiol ; Invited editorial on Pennes' paper revisited. An evaluation of the Weinbaum-Jiji equation for normal and hyperthermic conditions.
J Biomech Eng ; Najarian S, Pashaee A. Improvement of the Pennes Equation in the analysis of heat transfer phenomenon in blood perfused tissues. Biomed Sci Instrum ; Katchalsky A, Curran PF.