Manual Invisible Jenny May

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Those born in countries with high TB burden have a high risk of being infected. Children, people with chronic conditions such as diabetes and renal disease, and people with immune compromise are all at increased risk of disease progression if infected. In California, a high-incidence TB state with 5.

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Racial and ethnic minorities are disproportionately affected by TB disease. For example, diabetes is far more prevalent among Asians and Pacific Islanders and Hispanics with TB disease then in their White counterparts. Attention to racial and ethnic disparities and the social determinants that drive them has been a focus of national movements for a number of diseases including heart disease and cancer, and for HIV health outcomes. Beyond the arguments for equity and justice, this oversight is problematic for two reasons. First, as we achieve more effective implementation of TB prevention activities and drive down case rates, we should be wary of magnifying existing inequities.

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Unless interventions are effectively focused on the groups with the highest TB rates, benefits may disproportionately impact lower-risk subgroups. Recognizing risk disparities is the first step to designing specific interventions that target high-risk groups. Second, in failing to target the specific communities and populations most affected by TB, we lose an opportunity to make real progress toward TB elimination. Although local public health infrastructure generally includes programs focused on targeting TB disease attributable to recent transmission or importation, few programs exist to specifically address LTBI, the largest contributor to TB cases.

Partnerships with community clinicians, which would allow the provision of LTBI testing and treatment in primary care settings, are therefore urgently needed. Although the US Preventive Services Task Force recommends LTBI screening for asymptomatic adults who were born in or resided in countries with increased TB prevalence, 13 several factors conspire against widespread adoption of this practice in a primary care setting.

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Understanding the patient-level, provider-level, and health care system—level barriers to LTBI care is a first step in making TB prevention routine. The data published on patient-level barriers to LTBI care are limited and have focused on demographic factors such as age and medical factors including comorbidities and adverse effects of medication.


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In addition, there may also be uncertainty related to risk of developing disease for individuals with a positive test. Two additional barriers disproportionately affecting the non—US-born population may pose a threat to normalizing care for patients with LTBI.

For some persons born outside the United States, perceived threat about disclosing country of birth may deter care seeking for LTBI. In addition, immigrants to the United States may be less likely to have health insurance and encounter increased challenges to accessing the medical system. Although completion rates for LTBI therapy are improved with short-course regimens compared with the traditional isoniazid therapy, 16 lack of familiarity with these regimens remains an obstacle to treating LTBI in a primary care setting Jenna Feraud, California Department of Public Health, written communication, March 5, Insufficient funding of local TB programs means that the majority of LTBI care cannot be completed in public health clinics.

However, health systems obstacles limit care for patients in primary care clinics, which suffer from a lack of strategic planning and policies related to LTBI. Furthermore, poor coordination of laboratory and radiology services lead to delays in diagnosis and treatment, and inadequate methods for documenting LTBI care in medical records means that LTBI treatment completion is often challenging to document. Elimination of TB will not be achieved without attention to the reservoir of latent infection, which in the United States occurs largely in a non—US-born population of racial and ethnic minorities.

Reaching elimination targets will require specific efforts to 1. Some interventions can be put in place locally, such as facilitating linkage to care and developing culturally appropriate patient materials, while others will require more time-intensive actions at state and national levels. Clear guidance on testing and treatment must be disseminated by state and national organizations. Immigrants to the United States are a large and heterogeneous population; the obstacles and drivers of care for one group are not universal.

Understanding what motivates particular populations and targeting LTBI programs accordingly is critical to making progress. Culturally specific programs that address stigma, health care access, and language barriers are used in HIV and hepatitis C prevention 17,18 and may be helpful models in considering a path forward for TB control. Tailoring TB intervention content and modes of delivery to specific cultures, as well as selecting interventions that are least resource-intensive, may increase the success and feasibility of these programs.

Health care providers serve a critical role in ensuring that each person at risk for TB has an opportunity for testing and, if positive for infection, treatment. However, health care providers lack streamlined systems and incentives, and must juggle competing priorities. In addition, clear, simple instructions regarding which individuals are at risk, as well as how to test and treat those individuals, are critical.

Supporting research to develop the shortest, most acceptable regimens is clearly needed, but equally important is thoughtful dissemination of policy related to these regimens. To address current barriers faced by California residents and their health care providers, a TB elimination plan was published in California in that outlines actions for successful scale-up of LTBI testing and treatment statewide for high-risk populations.


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Measuring LTBI outcomes and creating more-effective mechanisms for reimbursement can also incentivize providers. Jenny Nimmo has always loved reading and writing. She read all the books in the junior school library and had to beg permission to join the senior school library when she was only nine.

Before becoming a full-time writer she was an actress, a stage manager and a floor manager for the BBC. She nows lives in a remote part of Wales and is probably best known for the Award winning Snow Spider Trilogy, stories that combine Welsh myth, the supernatural and family conflict. She says she enjoys writing about magic because it is inexplicable and unpredictable, and anything can happen.

She is currently working on a series of books called the Children of the Red King. The first of these 'Midnight for Charlie Bone' was published in and the latest installment, the fifth in the series is called 'Charlie Bone and the Hidden King' and was published in May Our Lists.

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