"Best Practices" for a Biospecimen Resource for the Genomic and Proteomic Era has conducted case studies of twelve existing human tissue repositories to.
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- Article Figures & Data
- Core 2: Tissue Core | Chronic Lymphocytic Leukemia Research Consortium (CRC)
- Case Studies of Existing Human Tissue Repositories
- Case Studies Existing Human Tissue Reposit...
Biospecimen and data collection and distribution.
Article Figures & Data
Practical factors in collecting tissues for research. Developing an operational framework: Standard workflows, operating, and quality control policies and procedures for the collection, storage, and distribution of frozen and paraffin-embedded tissue and blood. Prepared on behalf of DJ Kerr, D. Use of human tissues in research: J Investig Med Biosafety in Microbiological and Biomedical Laboratories [online].
Core 2: Tissue Core | Chronic Lymphocytic Leukemia Research Consortium (CRC)
Collection, processing, and analysis of preneoplastic specimens. Avoiding biohazards in medical, veterinary and research laboratories. Sample collection, processing and storage. Biological sample collection and processing for molecular epidemiological studies. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: Cytogenetic abnormalities in B-cell CLL are important prognostic indicators for predicting disease progression and treatment response.
Case Studies of Existing Human Tissue Repositories
This technology is useful to detect specific gene anomalies and various aneuploid conditions in neoplastic cells. FISH can be performed on blood and bone marrow aspirates or smears, paraffin embedded tissues, touch preparations, and many other tissue preparations.
Interphase FISH can be used to establish the percentage of neoplastic and normal cells in both interphase and metaphase cells before and after therapy, and therefore can be used to assess therapy and monitor remission. FISH-detected chromosome anomalies have also been associated with different clinical outcomes and may be associated with IGHv mutation status, CD38 expression, ZAP 70, antigen expression on leukemic B-lymphocytes, cell morphology and other biological features 2,3,27, Open full page PDF.
Epitope Variability in Immunohistochemistry.
Circadian Disruption and Prostate Cancer Risk. Exercise and Prostate Cancer. National Cancer Center, Singapore.
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Human tissue and biological samples for use in research operational and ethical guidelines. Medical Research Council, UK. International Society for Biological and Environmental Biorepositories.
Case Studies Existing Human Tissue Reposit...
National Cancer Institute, United States. Handbook of Human Tissue Resources: Research Involving Human Biological Materials: Ethical Issues and Policy Guidance. Research Involving Human Biological Materials….
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Issues to Consider in the Research Use of Stored…. Use of human tissues in research: Committee on Germplasm Resources, Division of…. Business Plan and Operations.
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How do the samples get transferred to the repository? Or are they stored locally? How do the samples get transferred to the….