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By Thea Jourdan for the Daily Mail. Welcome to the annual cold season. Most of us will get between one and three colds each year, usually in autumn and winter, caused by one of more than different cold viruses. And there is little you can do about it — a cure for the common cold remains one of the Holy Grails of medicine — but better understanding of how these viruses spread could be the key.

Do this one thing to stop a cold dead in its tracks

What we do know for sure is that the first 24 hours are crucial; this is when the infection takes hold and starts to multiply, causing symptoms. Here, with the help of three leading experts — Professor John Oxford, a virologist at Queen Mary University of London, Professor Ron Eccles, director of the Common Cold Centre at Cardiff University and Professor Peter Openshaw, a professor of experimental medicine at Imperial College London — we explain what is going on during the first 24 hours of your cold and what you can do to reduce the severity of your symptoms.

How To Treat A Cold - How To Cure Common Cold - Best Medicine For A Cold And Fever And Sore Throat

A better understanding of how cold viruses spread could be the key to stopping a cold stock image. A single sneeze contains hundreds of millions of virus particles known as virions — each of which can trigger a cold. Even those viruses that do reach the upper respiratory tract — the nose, mouth, throat and voice box — face another almost insurmountable obstacle stock image. Many millions of virus particles are also trapped in saliva and swallowed away.

Even those viruses that do reach the upper respiratory tract — the nose, mouth, throat and voice box — face another almost insurmountable obstacle. The epithelial cells that line these airways are so tightly bonded together, they usually provide an impermeable seal which keeps infections at bay.


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A cure for the common cold remains one of the Holy Grails of medicine stock image. Avoid rubbing your eyes with your hands, as this can transmit infection. By now the first symptoms — nasal dryness and irritation may be developing as the epithelial layer starts to break down. Applying a warm compress can provide relief — a clean flannel dipped into hot water and wrung out will do.

Or take a painkiller such as ibuprofen stock image.

8 Ways to Stop a Cold in the Early Stages

Where they settle depends on the type of virus that has infected you. Some viruses prefer the warmer environment of the upper lungs where it is 37c, while others focus on the nose and throat, partly because they prefer the lower 32c up there. Vicks First Defence claims to reduce the chance of a full-blown cold by up to 50 per cent if taken at the first sign of symptoms, and can cut the severity of those symptoms by 40 per cent.

This viscous gel, works by trapping the virus and helping the body remove it. The evidence for its effectiveness is not black and white, but it is supportive. In the first 24 hours, the infection takes hold and starts to multiply, causing symptoms stock image.

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Vicks First Defence claims to reduce the chance of a full-blown cold by up to 50 per cent if taken at the first sign of symptoms. It is now, as the virus infects more and more cells, that symptoms start to appear in earnest. Within hours, these chemicals are irritating and inflaming the lining of the nose, triggering sneezing — in an attempt to dislodge the virus.

Or take a painkiller such as ibuprofen. Cold viruses are now heavily established in the deeper levels of the epithelial cells and are moving through the bloodstream starting to interfere with the way cells work and creating symptoms like muscle ache. In particular, they affect genes that control cells in the nose and upper airway which produce and release mucus, causing over production as a way to ensure they can spread through airborne droplets — which is why people develop streaming noses and congestion in the sinuses.

Chicken soup, hailed for hundreds of years as a cold remedy, might help. Coughing occurs when tiny nerve cells in the lining of the respiratory tract — known as pulmonary irritant receptors — become sensitised by too much mucus. These send messages via the vagus nerve in the chest to the brain, which in turn orders the diaphragm and intercostal muscles between the ribs to contract violently, causing explosive coughing. The force of coughing rapidly damages the fragile epithelial lining of the respiratory tract, causing it to slough off and exacerbates a sore throat.

These short-term declines stem from temporary changes in the brain rather than cold or flu symptoms themselves, he said. Seasonal viruses reduce mental alertness by interfering with neurotransmitters such as noradrenaline, associated with reaction times. At a system-wide level, colds and flu trigger the body's attack mode, causing inflammation as the body works harder than usual to fend off illness. Of all the immunological changes involved in the cognitive effects of seasonal illnesses, he said, "inflammation is a key one.

Smith's interest in this area began in the mids, when Britain had a research unit that induced colds under experimental conditions. Pity the recruits who put up with stuffy noses in the name of science. The unit gave researchers such as Smith a unique opportunity to do "controlled, almost laboratory-like studies looking at the effects of these illnesses. Colds don't make us incompetent, however.

They affect our mental-processing speed more than accuracy, so we might just need more time to write that report or wrap our heads around a spreadsheet. But if our jobs involve driving or operating dangerous machinery, the cognitive effects of a sinus cold could be a safety issue.

How to Ease Cold Symptoms With an Herbal Cold Remedy

In a study published in BMJ Open, Smith asked 25 university students to complete a simulated driving exercise on two separate occasions. Fifteen volunteers had a cold in the first session but not the second, while 10 were healthy on both occasions. While their basic driving skills were unimpaired, those with colds were slower at responding to unexpected events — and detected fewer collision hazards.

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Does that mean we shouldn't drive under the influence of a sinus cold? Not necessarily.


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  • Simple things such as caffeine, ibuprofen, light exercise or a short nap can boost mental clarity, Smith says. In a study published in the journal Psychopharmacology, Smith compared reaction times in cold sufferers randomly assigned to receive milligrams of ibuprofen combined with milligrams of caffeine; ibuprofen or caffeine alone; or a placebo.

    Volunteers were tested twice over a three-hour period. Out of the four conditions, the ibuprofen-caffeine group showed the biggest improvement in reaction times. Caffeine not only increases mental alertness, but also amplifies the anti-inflammatory effects of the ibuprofen, Smith said. Both are active ingredients in many over-the-counter cold remedies. The cognitive effects of seasonal colds are tough to avoid, since more than viruses cause sinus colds.

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    6 WAYS TO STOP A COLD DEAD IN ITS TRACKS – passion for fresh ideas

    Customer help. Contact us. Log in. Log out. Article text size A. Open this photo in gallery:. Adriana Barton Health Reporter. Published November 2, Updated November 2, Published November 2, This article was published more than 2 years ago.