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GRAPE JUICE AS A THERAPEUTIC AGENT Digitized by Digitized by Google Dr. C.E. WELCH Founder and developer of the Grape Juice In dustry Digitized by.
Table of contents

Reduced the function of proteins in the pancreatic cancer cell membranes that are responsible for pumping chemotherapy out of the cell, making the cells chemo-sensitive. Triggered the production of reactive oxygen species ROS , which are substances circulating in the human body that have been implicated in a number of diseases: when ROS is increased, cells burn out and die.

Grape Mint Lemonade - Chaud's Juice Therapy

Caused apoptosis, which is likely the result of increased ROS. Radiation alone does not injure the mitochondrial membrane as much. The team also wanted to investigate why pancreatic cancer cells seem to be particularly resistant to chemotherapy. The pancreas, a gland located deep in the abdomen, produces insulin and regulates sugar, and pumps or channels powerful digestive enzymes into the duodenum. This natural pumping process, however, ends up ridding the needed chemotherapy from cells in the pancreas. In the same journal, Okunieff and his group also reviewed why resveratrol protects normal tissue, and found that antioxidants can be designed to take advantage of certain biochemical properties or cellular targets, making them more effective.

Examples of a component having an anti-fatigue effect include a mixture of coenzyme Q10 and carnitine JP-A and glutamine peptide JP-A and so on. However, their practical inhibitory effects on deterioration in endurance, muscle strength and energy metabolism and on muscle atrophy, each induced by aging, have not yet been studied.

Grape Seed Extract Kills Cancer Cells In Lab

Resveratrol is a polyphenol contained in grapes, wines made therefrom, and peanuts and it has been taken for long years. Resveratrol is reported to have an anti-cancer effect Science, , or an antiatherogenic effect Cardiovasc. Drug Rev. It is also reported to have a life-extending effect mediated by a molecule called Sir Nature, , On the other hand, a red grape leaf extract has traditionally been known as a therapeutic agent for venous incompetence and patents on a blood circulation improving method by a red grape leaf extract JP-A and a therapy for chronic venous incompetence JP-A are disclosed.

However, influences of resveratrol or grape leaf extract on motor performance including endurance and fatigue, and influences on aging-induced reduction in endurance and energy metabolism have been hitherto unknown. The present invention provides a drug, quasi drug and food each having high safety and exhibiting excellent endurance improving action, anti-fatigue action, motor function improving action, energy metabolism activating action, muscle strength improving action or anti-aging action.

Grape - health benefits and therapeutic value, tips on how to use it

The present inventors have searched for components effective for improving the body function. As a result, they we? The endurance improver, anti-fatigue agent, motor function improver, energy metabolism activator, muscle strength improver and anti-aging agent according to the present invention are useful as a food or drug exhibiting an endurance improving effect in sports and also broadly-defined exercises including activities of daily life and labors, an anti-fatigue effect, a motor function improving effect, an energy metabolism activating effect and a muscle strength improving effect.

They are also useful as a food or drug having effects of inhibiting aging-induced reduction in endurance, muscle atrophy, reduction in energy metabolism and reduction in muscle strength.

Bug attacks make organic fruits and veg healthier

In the present invention, at least one of them is used. Resveratrol of the present invention may be a glycoside piceid or the like. The resveratrol used for the present invention may be not only a high purity product synthesized in accordance with organic chemistry or by using a microorganism but also products obtained by extracting resveratrol-containing natural products such as grapes, peanuts, plants belonging to the family polygonaceae such as Japanese knotweed and then purifying the extract as needed.

And Plants, microorganisms, or extracts, partially purified products or processed products of various foods may also be used. Resveratrol isolated from these extracts, partially purified products or processed products may also be used. As the natural products, grapes and Japanese knotweed are preferred. Grapes can be classified into European grapes Vitis vinifera and American grapes Vitis labrusca. Either can be used, but European grapes are preferred. Examples of the grape extract include extracts available from grape berries, grape leaves and products derived from grapes.

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Of these, a grape leaf extract, especially a red grape leaf extract is preferred. A red grape leaf extract from European grapes Foliae Vitis vinifera L.

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Examples of the products derived from grapes include grape juice, wine, residues and juice which are by-products upon wine production, and wine concentrate. Since Resveratrol is contained much in skins or leaves of grapes, an ordinary extraction process of extracting them with water, hot water, aqueous alcohol, organic solvent or the like can be adopted for extraction. In addition, Resveratrol is also contained in grape juice, wine, concentrated juice or wine, or solid product obtained by concentrating them to dryness, so they can be provided for use.

As the organic solvent to be used for the extraction of resveratrol, alcohols such as ethanol are preferred, and ethanol is especially preferred. A Japanese knotweed contains much resveratrol in its root, so Japanese knotweed extract obtained by subjecting this portion to an ordinary extraction process similar to the above-described one is preferred. The endurance improver and the like are usable as a human or animal drug, quasi drug or food which is effective for improving endurance, preventing fatigue, improving muscle strength, improving motor function, activating energy metabolism and anti-aging.

Moreover, it can be used not only for those who are short of exercise, middle and aged persons or those needing bed rest, but also for all people including athletes. The physiological changes include reduction in endurance, muscle atrophy, reduction in energy metabolism and reduction in muscle strength. When the endurance improver and the like according to the present invention are employed as a drug or quasi drug, their dosage forms include orally administrable ones such as tablets, capsules, granules, powders and syrups, and parenterally administration ones such as injections, suppositories, inhalation drugs, percutaneous absorbents, and external preparations.

Of these dosage forms, oral administration is preferred. An orally administrable liquid preparation can be prepared in a manner known per se in the art by the addition of a taste corrigent, buffer, stabilizer and the like. When the endurance improver and the like according to the present invention are used as a food, they can be used in the forms of various foods such as breads, cakes, noodles, confectioneries, jellies, frozen foods, ice creams, milk products, beverages and soups and also in the forms similar to those described above in orally administrable preparations tablets, capsules, syrups and the like.

The beverages include fruit juices, carbonated beverages, tea beverages, near water drinks, sports drinks, milk beverages, alcoholic beverages and soft drinks. The foods thus prepared can be used as an endurance improving food, muscle strength improving food, motor function improving food, anti-fatigue food or anti-aging food or pet food having such a purpose. The endurance improver and the like according to the present invention can be used as a nutritional composition such as enteral nutrient for the elderly or patients needing bed rest who need feeding of an adequate amount of nutrients.

To foods, resveratrol is added usually in an amount of from 0. To drugs, for example, oral solid preparations such as tablets, granules and capsules and oral liquid preparations such as internal solutions and syrups, resveratrol is added usually in an amount of from 0. As resveratrol, that available from Cayman Chemical was employed. The flow rate was regulated by opening and closing of a valve of a water flow meter product of Tokyo Flow Meter Kenkyujo connected to the pump. To prevent a difference between groups in the maximal swimming time, mice were classified into two groups each consisting of 8 mice, that is, a test diet group and control diet group.

They were reared for 10 weeks on diets prepared according to the formulation as shown in Table 1.


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The maximal swimming time of mice on Week Ten after the rearing was started is shown in Table 2. Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation. Chronic consumption of purple grape juice in gestational-lactation and post lactation promotes anxiolity effect and antioxidant defense improvement in brain from Wistar male offsprings.

Neuroprotection against CCl 4 induced brain damage with crocin in Wistar rats. An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1 G93A mouse model of amyotrophic lateral sclerosis. Resveratrol suppresses ethanol stress in winery and bottom brewery yeast by affecting superoxide dismutase, lipid peroxidation and fatty acid profile.

Subchronic treatment with acai frozen pulp prevents the brain oxidative damage in rats with acute liver failure. Protective effects of some fruit juices with low-fat diet on rat testis damaged by carbon tetrachloride: A genetic and histological study. Dietary sweet cherry anthocyanins attenuates diet-induced hepatic steatosis by improving hepatic lipid metabolism in mice. Evaluation of antioxidant activity of grapevine leaves extracts Vitis labrusca in liver of Wistar rats.

Digestion property and synergistic effect on biological activity of purple rice Oryza sativa L. Assessment of changes in energy metabolism parameters provoked by carbon tetrachloride in Wistar rats and the protective effect of white grape juice. Biological Activities of Polyphenols from Grapes. CCl4 induces tissue-type plasminogen activator in rat brain; protective effects of oregano, rosemary or vitamin E. Antioxidant effect of organic purple grape juice on exhaustive exercise. Restorative effect of 5E, 13E —5,13—Docosadienoic acid on carbon tetrachloride induced oxidative stress in rats.

Black rice Oryza sativa L.


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Mineral content is related to antioxidant and antimutagenic properties of grape juice. Acetyl-l-carnitine prevents carbon tetrachloride-induced oxidative stress in various tissues of Wistar rats. Neuroprotective effects of anthocyanins on apoptosis induced by mitochondrial oxidative stress. In vitro and in vivo evaluation of antioxidant activity of Trichosanthes cucumerina aerial parts.