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Among a group of nearly 9, people who were enrolled in 11 studies in which they agreed to genetic analysis and were randomly assigned to a variety of weight loss methods, including diet, exercise or drug-based therapies, Mathers found the answer was a surprising no. While previous studies found that people with that variant were on average six to seven pounds heavier than people with other forms of the FTO gene, when it came to losing weight, there was no effect.

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And there were no differences among people with and without the FTO variant and their weight loss whether they tried dieting, exercise or weight-loss drugs. That should encourage people.

The results mirror those from previous studies of people with variants of the FTO gene, who were able to counteract the effects of their DNA and avoid excessive weight gain with exercise. You have to bite the bullet, and eat a bit less, or be more active [to maintain a healthy weight]. MyObesityTeam is the social network for those living with obesity.

Get the emotional support you need from others like you, and gain practical advice and insights on managing treatment or therapies for obesity. MyObesityTeam is the only social network where you can truly connect, make real friendships, and share daily ups and downs in a judgement-free place.

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Get the MyObesityTeam mobile app. MyObesityTeam is not a medical referral site and does not recommend or endorse any particular Provider or medical treatment. Almost there! Just a few more questions We use the answers below to make it easier to find others who are most similar to you — those who understand.


  • When Being Overweight Is a Health Problem (for Teens) - Nemours KidsHealth.
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