The Triple Whammy and Evolutions Demise

This scenario sets up what we call a triple whammy of harm. childhood failures, lack of motivation, and in extreme cases, sudden death.
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As stated, the powers delegated to Congress were enumerated in Article I, section 8. Naturalization, not immigration is listed. Clearly, sovereign entities states would be reluctant to surrender their authority to determine who can enter and live within their borders; local policy and social decision-making authority were to rest with the states. That is the very essence of the federal system that was consented to.

With a national system, such decisions affecting million people are made decided by a select few, sometimes even as few as five. The American War for Independence was fought to preserve a system of consent by the governed, where individuals were represented by local government bodies. California has elected to become a sanctuary state, and it should bear the responsibility for the burdens this policy creates.

Thanks to nationalism and the fact that states are merely a subsidiary of the whole, those who enter states with lax borders and sanctuary policies, may now burden other states, as they are free to travel and collect benefits across the Union. The founders and ratifiers took painstaking measures to ensure this would not happen, and to accept that federal domination over the states when it comes to immigration laws is to reject the notion that the states are capable of self-governance.

If we reject that, then we have surrendered our Revolutionary legacy. In many areas, states are indeed incapable by the very nature of the problem. If one state has strict border controls and a neighboring state has open borders, it's a recipe for disaster. Rogue states that give driver licenses to illegals with no safeguards preventing them from voting should have their electoral votes nullified. If you think arguing archaic points of law is tough now, wait until the USA is saddled with 60 million more mestizo invaders.

Wow, you take part of a point and still argue for an unconstitutional department and policy? And you call your self a conservative You know nothing of history, how the founding fathers had set this nation or what they intended. Until you do, be quiet. This outrage has nothing to do with separating children from parents. It's just about opening the borders. Thousands of children are separated from their parents every year. Both by the family courts who are known to alienate father's from their children in divorce cases. And cps also takes children away from loving families. But no one seems to care about that.

It's only the children at the border who are considered a humanitarian priority. This is just about pushing for open borders.

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The best solution would be immediate deportation upon discovery. If you catch illegals immediately deport the hole family without any chance of repeal. Just put them on the first plane back to their own country without exceptions. This way families can stay together. And the Western world can have a future. But the left will never agree to such protocols. Because this discussion has nothing to do with splitting up families. It's just about open borders. Supreme Court ruled in Zadvydas vs. Davis that "once an alien enters the country, the legal circumstance changes, for the due process clause applies to all persons within the United States.

In a Texas case, Plyler vs. Supreme Court ruled in that non-citizen children must get a free K education. In , Congress created expedited removal for undocumented immigrants without a hearing. Initially it only applied at the U. Then it was expanded to within miles of a border for undocumented immigrants who had been in the country less than 14 days. The issue of due process is at the heart of many immigration cases, including Reno v. Flores, the Supreme Court case that has returned to the spotlight with the surge in family separations.

The case led to an agreement requiring the government to release children to their parents, a relative or a licensed program within 20 days. The Supreme Court ruled in the case Gideon v Wainwright that if a person is too poor to hire an attorney, the government must appoint one.

The government can split up families in extraordinary circumstances, such as in the case of child abuse, but it cannot do so without going through a legal process THAT is where the issues are coming from right now. The Constitution does not prohibit anyone from voting. Instead, it spells out who cannot be denied the right to vote.

The 14th Amendment says men who are U. The 15th Amendment prohibits anyone from denying the right to vote based on skin color and the 19th Amendment prohibits denying the right to vote based on sex aka being a woman. First, in the case Plyler v. Doe, the Supreme Court ruled that if children who are citizens have access to a free, public education, so should undocumented immigrant children.


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And let us not forget, nothing in the constitution gives the federal government the right to manage immigration to begin with The "supreme" court has been wrong plenty of times, including upholding slavery, a tortured ruling to legalize abortion, anchor baby nonsense created by a single corrupt liberal judge, pretending a legal "right" to gay marriage existed in the ether all along, etc. Legalism won't save you from foreign barbarians who care nothing for our laws, beginning with immigration laws. But hey, keep reading from the binder as the mestizos flood in, until you don't recognize your own country anymore.

Are they the end all be all?

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But they are part of the system. Gay marriage was not illegal. It was not recognized, because of theocratic BS. The constitution doesn't say the people ,other than gays, can have this or that. The 14th amendment doesn't specify it covers only citizens. But it should not protect the parents from any legal ramifications. All i know is that white European people and cultures are facing extinction. I'm not from the USA.

I'm from Western Europe. And i don't give a dam about our constitution, the law or any court. I only care about the survival of my people. And mass migration is ruining my country and endangers the survival of my people and culture. And to save it we need to take some extreme steps. Just fully stopping immigration isn't enough anymore. We need to start mass deportation of first, second and third generation migrants. Tens of millions of people. Even those born here. I don't care if they call us nazi's. At this point i'm not even sure it was a good thing germany lost the second world war.

Maybe Europe would have been better off under nazi rule. Maybe we fought the wrong enemy. And if the US doesn't learn from Europe's mistakes. It will also parish. Expect a full third of shitlib Whites to die fighting FOR multicult suicide. There's so many things that are not in your constitution. It's all meaningless if the US doesn't survive anyway. I think you american people are lucky with your constitution. But without white Western people the US constitution is worthless.

Because immigrants don't care about the same values. In Europe we made the mistake of thinking these migrants would integrate. And now our societies are crumbling. Now we have millions of people living among us who hate us and our European values. And instead of becoming part of our societies. They are slowly taking over Europe. And as soon they have the numbers they'll kill all white men and take the women by force. We are being conquered. You shouldn't get stuck on your constitution and Supreme Court so much.

It won't stop the migrants from enforcing their own laws when they have the numbers to do so. It is not even close to what our founders wanted. To even bring race into it speaks far more about you than anyone else. And it is sad honestly. You said yourself you're not in the US, so don't presume. Not the first time. Then rule of law would be meaningless, would bring chaos and anarchy, which would make things worse. In times of civil war there's only one law. And it's the law of the jungle. The strong eat the weak. Kill or be killed.

There is no place for moral values when fighting for survival.

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Good or evil has nothing to do with it. If you want to live, you'll have to kill the enemy. Civil war is the most brutal type of war there is. If you don't want to be part of it, there's only one thing to do. Become a migrant yourself and leave the Western world.

Why it is urgent to reunite immigrant children with their parents now.

Because it can start any day now. There will be no peace. There will be no rule of law. Only fire and blood for everyone. What did you expect what would happen?


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    4. Did you really believe everyone would become friends and hold hands? That's not how human nature works. Humans are terratorial and tribal animals. They kill for dominance, resources and the opportunity to reproduce. Peace is just a short break in between fights. Without it, the person is nothing more than a beast, not human. Honor is a noble idea. I use to believe in it. It was drilled into me from age 7. But strangely it didn't even cross my mind once when i was fighting for my life soaked in my own blood. Look around and try to find 5 honorable men. Good luck finding them.

    The only honorable thing you'll find in war is between you and the man fighting at your side. All the rest go's right out the window when the fighting starts. All different races, religions Most people don't even know what honor means. But i doesn't even matter. They all shit themselves all the same when things start to get ugly. It doesn't matter who dies with honor and who doesn't. All that matters is who's left standing when it's over. He will write the history books. Full of stories about honor and glory.

    Full of lies to sell his politics. I want my people to survive. I don't care for meaningless words of praise. I don't care about medals, flags, bronze statues or victory parades. Just surviving is good enough for me. Making it seem honorable afterwards is the politicians, the journalists and historians job. Why don't you go tell those thousands of homeless war veterans about honor. Explain to them why you have to take care of the migrants while they are begging for food. Not getting the medical care they need. You don't take care of the people who gave everything for their country.

    But somehow you're all great humanitarians because you take care of people who don't even have the right to be there. Is that what you mean with honor? If that's honor, i can do without. What about their children? Who have to grow up without their father. Further studies will be needed to clarify this.. Different crystals may cause kidney injury through shared molecular and cellular mechanisms. However, tubular cells can contribute to promote inflammation, since they internalize CaOx leading to cell death by necrosis and release of DAMPs such as ATP that activate the inflammasome in immune cells.

    DNA fragmentation and annexin V binding. Both renal intrinsic cells and inflammatory cells contribute to inflammation during kidney injury. Monocytes are recruited by damaged tubular cells and differentiate into inflammatory macrophages that secrete cytokines and chemokines causing additional renal inflammation and damage.

    Inflammation and immune cells can also play a role in recovery from kidney injury. In late stages of injury macrophages may differentiate to the M2 phenotype that resolves inflammation and promotes tissue recovery. In fact, Tregs suppress inflammation by secreting anti-inflammatory cytokines and promote tubular proliferation.

    From the 90s apoptosis was considered the major pathway of cell death in AKI. This made it difficult to find a link between cell death and inflammation. However, the newly described contribution of regulated necrosis to AKI has opened a new field in the research on renal inflammation, since necrosis does promote inflammation. In necroinflammation, necrotic cells release DAMPs and alarmins, 86 which have immunostimulatory properties and activate innate immune responses and nonimmune cells, such as parenchymal renal cells, 87 triggering inflammation, which subsequently can generate more cell death by different mechanisms, in an auto-amplification loop of necrosis and inflammation that drives to acute organ dysfunction, organ failure, or even a systemic inflammatory response syndrome which can lead to multiple organ failure.

    FA-AKI could represent a good model to study necroinflammation because ferroptosis promotes the expression of Fn14 and kidney inflammation. Preclinical studies have identified several pathways resulting in regulated necrosis that can be successfully modulated in AKI in vivo by drugs or interventions targeting the molecular pathways leading to regulated necrosis. Evidence has been obtained both for the potential contribution of different forms of regulated necrosis to the same model of AKI and for differences in the regulated necrosis forms relevant for diverse forms of AKI.

    Clinical development of drugs targeting regulated necrosis should be ideally associated to companion diagnostics developments that allow the early identification of the occurrence of diverse forms of cell death, ideally before renal function has decreased. Thus, approaches targeting regulated necrosis in clinical trials may consist on prophylactic administration of one or several compounds targeting one or several regulated necrosis pathways prophylactically in high risk situations such as patients undergoing heart surgery or in preservation solutions used for kidney grafts.

    The potential benefits may include prevention or decreasing the severity of AKI and, in the kidney transplantation context, reduce the immunogenicity of the graft. As an alternative, the drugs may be tested in patients that are monitored by companion diagnostics kits, aiming at identifying in urine features of ongoing regulated necrosis, and therapy started once the earliest features of kidney regulated necrosis are detected. In the nineties, the description of the molecular regulation of apoptosis raised hopes of therapeutic interventions in diseases conditions characterized by massive cell death, such as AKI.

    Unfortunately, the hype did not materialize into changes in clinical practice. It is likely that in the future several forms of cell death are targeted simultaneously. The clinical applications may range from AKI, the condition most studied to date given the magnitude of cell death and the convenient logistics, to CKD or kidney graft preservation. Further studies are needed to define which specific forms of cell death should be targeted in each condition or whether a standardized anti-cell death cocktail targeting several cell death modalities may be applied to diverse clinical conditions.

    Agents better suited for clinical use should be developed or ideally, drugs that have already proved safe should be repurposed in order to accelerate clinical translation. Unlike apoptosis, regulated necrosis promotes an inflammatory response necroinflammation which can explain the relation between cell death and inflammation during renal injury.. Of interest to kidney transplantation, necroinflammation is immunogenic..

    The description of new pathways of regulated necrosis and early preclinical evidence of success in nephroprotection by targeting these pathways, have raised hopes of novel therapeutic approaches to prevent both renal cell death and inflammation.. Further studies with specific inhibitors of regulated necrosis are needed to discern the specific pathway activated in each kidney disease.. The authors declare that they have no conflicts of interest.. Previous article Last Issue Next article. Related Articles in Nefrologia. We now review the different modalities of regulated necrosis, the evidence for a role in diverse forms of kidney injury and the new opportunities for therapeutic intervention.

    Introduction Acute kidney injury AKI is characterized by a rapid decline of renal function and its incidence is increasing. Cell death during AKI For many years the term acute tubular necrosis was used to refer to AKI characterized by parenchymal renal injury of mainly tubular location. The main difference between apoptosis and necrosis is that apoptosis is not inflammatory because the integrity of the plasma membrane is maintained; while in necrosis plasma membrane integrity is lost leading to the release of molecules that trigger inflammation and immunogenic responses.

    Targeting regulated cell death in experimental AKI. Lancet, , pp. Drug-related acute renal failure in hospitalised patients. Nefrologia, 35 , pp. A comparison of acute kidney injury classification systems in sepsis. Nefrologia, 36 , pp. Expert Opin Drug Discov, 10 , pp.

    From the nephrologist's point of view: Clin Kidney J, 8 , pp. J Am Soc Nephrol, 23 , pp. J Am Soc Nephrol, 26 , pp. The morphology of acute tubular necrosis in man: Medicine Baltimore , 58 , pp. Tubular ultrastructure in acute renal failure in man: Pathol Anat Histopathol, , pp. The proximal tubule is the primary target of injury and progression of kidney disease: Am J Physiol Renal Physiol, , pp. TLR4-mediated inflammation is a key pathogenic event leading to kidney damage and fibrosis in cyclosporine nephrotoxicity. Arch Toxicol, 91 , http: J Am Soc Nephrol, 19 , pp.

    Mitogen-activated protein kinase 14 promotes AKI. J Am Soc Nephrol, , http: J Am Soc Nephrol, 25 , pp. Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury. Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis. Biosci Rep, , pp. Mechanisms of renal apoptosis in health and disease.

    Science, , pp. Kidney injury marker 1 and neutrophil gelatinase-associated lipocalin in chronic kidney disease. KIMmediated phagocytosis reduces acute injury to the kidney. J Clin Invest, , pp. Kidney Int, 80 , pp. J Am Soc Nephrol, 27 , pp. Nonapoptotic cell death in acute kidney injury and transplantation.

    Kidney Int, 89 , pp. Macrophages and recently identified forms of cell death. Int Rev Immunol, 33 , pp. Programmed necrosis in inflammation: Cytokine cooperation in renal tubular cell injury: Kidney Int, 70 , pp. Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Kidney Int, 81 , pp. J Am Soc Nephrol, 24 , pp. Nat Commun, 7 , pp.

    Análisis dirigido de la necrosis regulada en la enfermedad renal

    Cell, , pp. Synchronized renal tubular cell death involves ferroptosis. Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid-induced AKI. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol, 16 , pp.

    BASP1 promotes apoptosis in diabetic nephropathy. J Am Soc Nephrol, 21 , pp. Redox homeostasis, T cells and kidney diseases: Clin Kidney J, 9 , pp. T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J Exp Med, , pp. Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res, 26 , pp. Uromodulin, inflammasomes, and pyroptosis.

    Ischemia-reperfusion induces renal tubule pyroptosis via the CHOP-caspase pathway. Of Inflammasomes and Alarmins: Nat Rev Drug Discov, 15 , pp. Cyclophilin D and the mitochondrial permeability transition in kidney proximal tubules after hypoxic and ischemic injury. Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia.

    Am J Pathol, , pp. Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models. Kidney Int, 84 , pp. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. Molecular mechanisms of crystal-related kidney inflammation and injury Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease.

    Nephrol Dial Transplant, 29 , pp. Semin Nephrol, 23 , pp. Cellular and molecular studies on cisplatin-induced apoptotic cell death in rat kidney. Arch Toxicol, 78 , pp. Necrotic concentrations of cisplatin activate the apoptotic machinery but inhibit effector caspases and interfere with the execution of apoptosis. Toxicol Sci, , pp. Synergistic effect of apoptosis and necroptosis inhibitors in cisplatin-induced nephrotoxicity.