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Table of contents
- Sounds and Speech as a window into the Brain.
- Funniest Uncensored Adult Jokes & Hilarious Adult Memes Book 2: Uncensored and Explicit Funny Jokes, Puns, Comedy N Truly Tasteless Jokes;
- Advanced Targeting Systems – Target cells specifically using cell-surface markers.
- Quantum Break: Zero State.
- My Own Winter Sun.
- The Supremest Human Being Part-2 (The Supremest Human Being Series)!
- Category: SfN.
Kennedy, a Democratic Congressman, on Monday called for a focused national program to uncover the causes and treatments for brain disorders. The challenge today, he told SFARI, is to devote enough resources for research on disorders such as autism. Ricardo Dolmetsch is making neurons from induced pluripotent stem cells derived from people with Timothy syndrome, a rare single-gene disorder that causes heart arrhythmias and autism.
Young children with autism have high urine levels of a compound that is likely to be a product of gut bacteria, according to a poster presented Tuesday at the Society for Neuroscience annual meeting in San Diego.
Friday, November 19, 2010
Pregnant mice injected with the immune protein interleukin-6 give birth to pups that are less social than normal, an effect that results from the over-activation of two pathways critical in neurodevelopment, researchers reported Tuesday at the Society for Neuroscience annual meeting in San Diego. Rapid advances in DNA sequencing technology are enabling researchers to comb quickly — and ever more cheaply — through whole genomes.
You can read a lay-friendly summary of the paper, and check out our quote-tastic opinions of our own work, on the departmental website , and the story has already been picked up by others too! Overall the meeting was great, with a nice buzz around the meeting halls, some impressive plenaries, and a lot of really useful contacts made. Plus everyone apart from Matt made the most of being in the US afterwards: Elisa to go and visit her collaborators at Harvard, Adna to scope out potential post-docs in New York, and Annisa went to see the Space Shuttle Discovery.
Society for Neuroscience 2010
While we were in DC our newest lab member Darren held the fort admirably, and even generated some quality data! Matt recently interviewed to become an inaugural member of the FENS-Kavli Network of Excellence , and spent a fantastic day advising the Theatre-Rites production company on its plans for building a human brain to stick in a puppet. It has been used for decades as a physiological model of memory formation. How do the physiological properties of new neurons translate to a behavioral role?
Are they just like mature neurons or are they unique? While we know that hippocampal neurons are already plastic and very capable of physiologically linking together different stimuli the big hope seems to be that maybe immature neurons are even better at this. A related question is how fewer synapses and unique inhibitory connectivity affects their information processing capabilities. The verdict is out on whether new neurons are more or less involved in information processing than their mature counterparts. Currently, the best information we have is from studies looking at activity, measured by immediate early gene expression, in response to behavioral stimulation.
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On the other hand, new neurons synapses are more plastic, perhaps making them better able to associate information even if they have fewer synapses. So next year I vow to present something really boring. Of course, much can be learned while pinned down at your own poster.
When you work in one lab, or one institution, your thoughts about the brain tend to have a specific focus based on the ideas of the people around you. Of course, new papers come out that challenge those thoughts but, man, papers move slooooowly.
SfN Day 2 (also late)
Scientists have not done a stellar job of using the internet to quickly communicate ideas. However, once a year at SFN a whole bunch of people come to your poster and give you their thoughts on the brain. I had several visitors who specifically came by because they knew about me through the blog and through Twitter.
Thank you for stopping by! You often never know if your online thoughts are useful, but I was happy to hear that several of you have used the blog as a teaching tool and a way to keep up with the field. I wish I could have these interactions with my readers more often than once a year at SFN. Do you know how many in vivo electrophysiologists are on Twitter? Like, one? And how many experts are reviewing the literature on Research Blogging? Your knowledge is valuable. I would follow you in an instant. Adult neurogenesis is a great example of the more you learn the more confused you get!
Things may have seemed congruent 5 years ago but that was when there was only half a dozen studies that had examined the problems that arise when new neurons are ablated. Since then people have gone on to study more types of behavior and, as is also the case with the hippocampus, new neurons have been found to contribute to more and more types of behaviors.
This has also given us additional opportunities for failed replication, and therefore doubt and confusion. One visitor commented on the recent paper that found memory impairments only if you kill new neurons after learning and we agreed that killing new neurons before behavioral testing could allow for other neurons to compensate, and make it appear that these new neurons are not doing anything significant.