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- Description
- Expected Boost in the Vials Market Growth
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- The Vials of Eternity - Wowpedia - Your wiki guide to the World of Warcraft
From the glory of God and from His power smoke fills the temple. None can therefore approach to intercede. There can be no more delay: long-suffering patience is exhausted: "no one was able to enter into the temple until the seven plagues of the seven angels were fulfilled. The vials of wrath are now poured out upon the earth at the bidding of a great voice from the temple.
The wrath of God is no mere ebullition of passion that carries away the subject of it. It waits the word from the sanctuary; and at length that eventful word is spoken. Completing the divine judgments, the range of the vials is not narrower than that of the prophetic earth, and in this, differ from the trumpet-series which otherwise they much resemble. Another resemblance which is significant is to the plagues of Egypt, which were at once a testimony to the world and for the deliverance of Israel.
Israel is here also in her last crisis of trouble, and waiting for deliverance, for which these judgments, no doubt, prepare the way, though that which alone accomplishes it, the coming of the Lord Himself, is not plainly included. The first vial is poured out distinctively, in contrast with the sea and rivers, etc. In Egypt such a plague routed their wise men so that they could not stand before Moses. According to the natural meaning of such a figure, it would speak of inward corruption which is made now to appear outwardly in what is painful, loathsome, and disfiguring; those who had accepted the beast's mark being thus otherwise marked and branded with what is a sign of their moral condition.
As the apostle shows Rom. Here it is openly the worship of the image of him whom Scripture stamps as the "beast," which those branded with his mark give themselves up to. The excesses of the French revolution, when God was dethroned to make way for a prostitute on the altar of Notre Dame, if they be not, as some have thought them, the fulfillment of this vial, may yet sufficiently picture to us how it may be fulfilled in a time of trouble such as never was before, and, thank God, such as never will be afterward.
The second vial is poured out on the sea, and the sea becomes like the blood of a dead man, and every living soul dies in the sea. Here we have the second trumpet in its effect upon the sea, but without the limitation there. And there seems a difference also, in that the blood is as of a dead man. It cannot be that it is merely dead blood, for all blood shed becomes that almost at once, and the sea turned into blood would by itself suggest death without the addition.
Would it not rather seem to be, that the blood of a dead man, while it is indeed dead blood, is also that which has not been shed? Life has not been violently taken, but lost through disease or natural decay. Thus in the law that which had died of itself was forbidden as food, because it spoke of internal corruption, as the life still vigorous when the blood was shed did not. If this thought be the true one, then the state imaged under the second vial is not that of strife and bloodshed among the nations, but of professed spiritual life gone, which the addition, "Every living soul died in the sea," affirms as complete.
Life there might be in hunted and outlawed men, no longer recognized as part of the nations; but the mass was dead. This seems to me the only thought that gives consistently the full force of the expressions. The third vial is poured out upon the rivers and fountains of waters, the sphere affected by the third trumpet; but in the trumpet they are made bitter, now they become blood, which, as owned to be the judgment of God upon persecutors, seems clearly to speak of bloodshed: they are given blood to drink.
Where naturally there should be only sources of refreshment, as perhaps in family life, there are found instead strife and the hand of violence. The angel of the waters may be in this case the representative of that tender care of the Creator over the creature-life, which in this case comes to be against the persecutor and applauds His judgments; as the altar does, upon which the lives of the martyrs have been poured out to God. The fourth angel pours his vial upon the sun, and it scorches men with its heat; but they only blaspheme God's name, and repent not.
Here, as often, the head of civil authority seems to be represented; and Napoleon's career has been taken as in the historical application the fulfillment of it. In him after the immorality, apostasy, and bloodshed of that memorable revolution, imperial power blazed out in a destructive fierceness, that might well be symbolized as scorching heat. There was splendor enough, but it was not "a pleasant sight to behold the sun:" the nation over which he ruled was oppressed with "glory," and soon manifested how its vitality had been exhausted by its hot-house growth.
His career was brief; and briefer still in proportion to its intensity will be the closing despotism, which will be followed by the kingdom of the Son of Man, and the display of a true glory unseen by the world before. Then shall that be fulfilled which is written: "the Sun shall not smite thee by day," and how great will be the joy of this that is added, "thy Sun shall no more go down;.
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The fifth vial is poured out, and the meteoric blaze is passed. Poured on the throne of the beast, darkness spreads over his kingdom. On a routine surface sample taken from a chamber shelf after sterilization and processing, a high count of Pseudomonas sp.
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After sterilization and cooling when the chamber door was opened, condensate routinely spilled onto the floor from the door. A surface sample taken from the floor below the door also revealed Pseudomonas sp. Since the company believed the condensate remained in the chamber after sterilization, they repiped the chamber drain and added a line to a water seal vacuum pump.
There are several aspects of finished product testing which are of concern to the lyophilized dosage form. These include dose uniformity testing, moisture and stability testing, and sterility testing. The USP includes two types of dose uniformity testing: content uniformity and weight variation. It states that weight variation may be applied to solids, with or without added substances, that have been prepared from true solutions and freeze-dried in final containers. However, when other excipients or other additives are present, weight variation may be applied, provided there is correlation with the sample weight and potency results.
For example, in the determination of potency, it is sometimes common to reconstitute and assay the entire contents of a vial without knowing the weight of the sample. Performing the assay in this manner will provide information on the label claim of a product, but without knowing the sample weight will provide no information about dose uniformity. One should correlate the potency result obtained form the assay with the weight of the sample tested.
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An obvious concern with the lyophilized product is the amount of moisture present in vials. The manufacturer's data for the establishment of moisture specifications for both product release and stability should be reviewed. As with other dosage forms, the expiration date and moisture limit should be established based on worst case data. That is, a manufacturer should have data that demonstrates adequate stability at the moisture specification.
Expected Boost in the Vials Market Growth
As with immediate release potency testing, stability testing should be performed on vials with a known weight of sample. For example, testing a vial sample which had a higher fill weight volume than the average fill volume of the batch would provide a higher potency results and not represent the potency of the batch. Also, the expiration date and stability should be based on those batches with the higher moisture content. Such data should also be considered in the establishment of a moisture specification.
For products showing a loss of potency due to aging, there are generally two potency specifications. There is a higher limit for the dosage form at the time of release. This limit is generally higher than the official USP or filed specification which is official throughout the entire expiration date period of the dosage form. The USP points out that compendial standards apply at any time in the life of the article. Stability testing should also include provisions for the assay of aged samples and subsequent reconstitution of these aged samples for the maximum amount of time specified in the labeling.
On some occasions, manufacturers have established expiration dates without performing label claim reconstitution potency assays at the various test intervals and particularly the expiration date test interval.
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Additionally, this stability testing of reconstituted solutions should include the most concentrated and the least concentrated reconstituted solutions. The most concentrated reconstituted solution will usually exhibit degradation at a faster rate than less concentrated solutions. With respect to sterility testing of lyophilized products, there is concern with the solution used to reconstitute the lyophilized product. Bacteriostatic Water For Injection may kill some of the vegetative cells if present as contaminants, and thus mask the true level of contamination in the dosage form.
As with other sterile products, sterility test results which show contamination on the initial test should be identified and reviewed. This includes sterile lyophilized powders. Critical aspects would include the presence of correct volume of cake and the cake appearance.
The Vials of Eternity - Wowpedia - Your wiki guide to the World of Warcraft
With regard to cake appearance, one of the major concerns is meltback. Meltback is a form of cake collapse and is caused by the change from the solid to liquid state. That is, there is incomplete sublimation change from the solid to vapor state in the vial. These may result in greater instability and increased product degradation. Another problem may be poor solubility.
Increased time for reconstitution at the user stage may result in partial loss of potency if the drug is not completely dissolved, since it is common to use in-line filters during administration to the patient. Manufacturers should be aware of the stability of lyophilized products which exhibit partial or complete meltback.
Literature shows that for some products, such as the cephalosporins, that the crystalline form is more stable than the amorphous form of lyophilized product. The amorphous form may exist in the "meltback" portion of the cake where there is incomplete sublimation. The pressure exerted at the earth's surface by the atmosphere. For reference purposes a standard atmosphere is defined as torr or millimeters of mercury, or , microns.
A process that occurs at low chamber pressures where hydrocarbon vapors from the vacuum system can enter the product chamber. This pump is positioned between the mechanical pump and the chamber. It operates by means of two lobes turning at a high rate of speed. It is used to reduce the chamber pressure to less than 20 microns.
Admitting air or a selected gas to an evacuated chamber, while isolated from a vacuum pump, to raise the pressure towards, or up to, atmospheric.