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Advances in Clinical Chemistry. The serial discusses the latest, most up-to-date technologies related to the field of clinical chemistry. It is the benchmark publication for novel analytical approaches in the clinical laboratory.
Table of contents
- Series: Advances in Clinical Chemistry
- Clinical Exome Sequencing Tests Are Frequently Incomplete: Study | The Scientist Magazine®
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- Myths and Legends of Our Own Land — Volume 06 : Central States and Great Lakes.
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- Passion on the 5th (NASA Weekend Series Book 1).
- Advances in Clinical Chemistry: Volume 81.
- Circulating Biomarkers in Malignant Melanoma.
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This impact factor places Clinical Chemistry in the top 2. Laboratory medicine professionals provide essential answers to clinicians so that patients get the care they need—from diagnosing the flu to identifying the therapies that cancer patients will respond to best.
As the most trusted and authoritative journal in laboratory medicine, Clinical Chemistry strives to advance the field by showcasing vital research that holds the key to challenging patient health problems. Every year, Clinical Chemistry publishes 2, pages of peer-reviewed papers that drive clinical testing forward and are chosen based on the novelty of their findings as well as the high quality of the scientific evidence they present.
These papers cover timely subjects ranging from designer drugs to emerging technology, such as mass spectrometry, that is transforming the way medical tests are performed.
Series: Advances in Clinical Chemistry
In particular, due to the steadily increasing prevalence of metabolic disorders such as diabetes mellitus, an adequate control of the circulating amount of insulin is desirable. In addition, also in forensics and doping control analysis, the determination of insulin in blood, urine or other biological matrices plays a major role. However, in order to establish general reference values for insulin and C-peptide for diabetology, the comparability of measured concentrations is indispensable.
This has not yet been fully implemented, although enormous progress has been made in recent years, and the search for a "gold standard" method is still ongoing. Meanwhile, also high-throughput measurements have been realized to meet the requirement of testing a high number of samples in a short period of time. Further developments aim at enabling the online measurement of insulin in the blood with the help of an insulin sensor and, in the following, in addition to a brief review, today's state of the art testing developments are summarized.
Lectin biosensors in cancer glycan biomarker detection. Cancer has high incidence and it will continue to increase over the next decades.
Clinical Exome Sequencing Tests Are Frequently Incomplete: Study | The Scientist Magazine®
Detection and quantification of cancer-associated biomarkers is frequently carried out for diagnosis, prognosis and treatment monitoring at various disease stages. It is well-known that glycosylation profiles change significantly during oncogenesis. Aberrant glycans produced during tumorigenesis are, therefore, valuable molecules for detection and characterization of cancer, and for therapeutic design and monitoring. Although glycoproteomics has benefited from the development of analytical tools such as high performance liquid chromatography, two-dimensional gel and capillary electrophoresis and mass spectrometry, these approaches are not well suited for rapid point-of-care POC testing easily performed by medical staff.
Lectins are biomolecules found in nature with specific affinities toward particular glycan structures and bind them thus forming a relatively strong complex. Because of this characteristic, lectins have been used in analytical techniques for the selective capture or separation of certain glycans in complex samples, namely, in lectin affinity chromatography, or to characterize glycosylation profiles in diverse clinical situations, using lectin microarrays. Lectin-based biosensors have been developed for the detection of specific aberrant and cancer-associated glycostructures to aid diagnosis, prognosis and treatment assessment of these patients.
The attractive features of biosensors, such as portability and simple use make them highly suitable for POC testing. Recent developments in lectin biosensors, as well as their potential and pitfalls in cancer glycan biomarker detection, are presented in this chapter. Amino and organic acid analysis: Essential tools in the diagnosis of inborn errors of metabolism. Inborn errors of metabolism IEMs are a large class of genetic disorders that result from defects in enzymes involved in energy production and metabolism of nutrients. For every metabolic pathway, there are defects that can occur and potentially result in an IEM.
While some defects can go undetected in one's lifetime, some have moderate to severe clinical consequences. In the latter case, the biochemical defect leads to accumulation of metabolites and byproducts that are toxic or interfere with normal biological function.
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Disorders of amino acid metabolism, organic acid metabolism and the urea cycle comprise a large portion of IEMs. Return to Book Page. Advances in Clinical Chemistry by Gregory S.
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Makowski Editor. Advances in Clinical Chemistry, Volume 92, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry. It is the benchmark publication for novel Advances in Clinical Chemistry, Volume 92, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists.
Top Authors
It is the benchmark publication for novel analytical approaches in the clinical laboratory. Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science Authored by world renowned clinical laboratory scientists, physicians and research scientists Presents the international benchmark for novel analytical approaches in the clinical laboratory Get A Copy.
Hardcover , pages. Published September 12th by Academic Press first published September 17th More Details Other Editions Friend Reviews. To see what your friends thought of this book, please sign up.