The Labbitt Halsey Protocol

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Table of contents

Cancer Discov 3 7: Prevention of autoimmune diabetes and induction of beta-cell proliferation in NOD mice by hyperbaric oxygen therapy. J Pathol 2: Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model. Exp Cell Res Dendritic cells directly trigger NK cell functions: Nat Med 5 4: Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis.

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection. Receptor for advanced glycation end-products RAGE provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Cell Immunol 1: Int Immunol 23 2: Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism.

Mol Cell Biol 32 DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of Beta interferon coexpression on vaccine properties. J Virol 88 4: Targeting NF-kappaB in glioblastoma: Sci Adv 2 1: Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice. PLoS One 5 1: Inefficient double-strand break repair in murine rod photoreceptors with inverted heterochromatin organization.

Genetic overview

Curr Biol 24 A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation. Full reconstitution of the immune deficiency in scid mice with normal stem cells requires low-dose irradiation of the recipients. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest 94 6: Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors. Exp Parasitol 98 1: Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited.

Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapy. Brain Res Bull 74 6: Scarless skin repair in immunodeficient mice. Wound Repair Regen 14 3: Glucocorticoid signalling affects pancreatic development through both direct and indirect effects. Interplay between paracrine signaling and gap junctional communication in ovarian follicles.

J Cell Sci Pt 1: Mol Cancer Res 4 5: Cancer Cell 3 1: Polymorphism of histocompatibility genes in the mouse. Transplant Proc 2 1: Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae. Eur J Immunol 32 4: Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. Cancer Cell 33 5: MyD88 is required for the formation of long-term humoral immunity to virus infection.

Specificity-based negative selection of autoreactive B cells during memory formation. Genes Dev 10 Curr Biol 11 3: Cancer Res 58 Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.

Retinoic-Acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: J Virol 69 1: Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Elongated telomeres in scid mice.

Biochem Biophys Res Commun 3: Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection. Cancer Cell 31 1: Transfer of Sjogren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment. Eur J Immunol 24 Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice. J Infect Dis 3: Pathogenicity of T helper 2 T-cell clones from T-cell receptor transgenic non-obese diabetic mice is determined by tumour necrosis factor-alpha.

Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner. PLoS Pathog 11 4: Effect of the mouse scid mutation on meiotic recombination. Mamm Genome 7 7: Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice. J Leukoc Biol 84 2: Resistance to the African trypanosomes is IFN-gamma dependent. J Infect Dis 4: Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.

Long-term lymphoid reconstitution of SCID mice suggests self-renewing B and T cell populations in peripheral and mucosal tissues. Exp Anim 50 1: J Cell Biol 2: Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell 8 4: TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest IL production by NK cells: Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining. Hum Mol Genet 14 CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury.

Exp Eye Res Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-beta. Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis.

IL is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 51 5: Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. Mammary gland development in transforming growth factor beta1 null mutant mice: Biol Reprod 79 4: Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest. Existence of a threshold-like dose for gamma-ray induction of thymic lymphomas and no susceptibility to radiation-induced solid tumors in SCID mice.

Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts. Exp Hematol 40 The usefulness of severe combined immunodeficiency SCID mice to study human carcinogenesis. Cancer Lett 88 1: Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.

Diabetogenic T cells are primed both in pancreatic and gut-associated lymph nodes in NOD mice. Eur J Immunol 33 Disruption of the Jnk2 Mapk9 gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Infect Immun 79 MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis.

Genes Dev 28 Defective killing of Candida albicans hyphae by neutrophils from beige mice. J Infect Dis 6: Biochim Biophys Acta The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. Leydig cell function in mice lacking connexin Tumours with PI3K activation are resistant to dietary restriction. Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts. PLoS One 12 6: HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-kappaB pathway.

Cancer Lett 1: Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. Immunological control of methicillin-resistant Staphylococcus aureus MRSA infection in an immunodeficient murine model of thermal injuries. Eur J Immunol 31 4: RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Res 73 1: Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.

Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis. Cancer Res 65 5: Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis. J Leukoc Biol 76 6: A crucial role for B cells in neuroinvasive scrapie [see comments] Nature Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth. The Bcl-2 homology domain 3 BH3 -only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.

Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice. Clin Exp Rheumatol 16 6: TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity. Endothelial interleukin-6 defines the tumorigenic potential of primary human cancer stem cells.

Stem Cells 32 MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo. Infect Immun 80 8: A cutaneous gene therapy approach to human leptin deficiencies: Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone. IL deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses.

Mobilization studies in complement-deficient mice reveal that optimal AMD mobilization of hematopoietic stem cells depends on complement cascade activation by AMDstimulated granulocytes. Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes.

Nat Commun 9 1: Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 15 Islet antigen-specific Th17 cells can induce TNF-alpha-dependent autoimmune diabetes. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. Dual functional monoclonal antibody PF targets integrin alpha5beta1 and elicits potent antibody-dependent cellular cytotoxicity.

Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes. Lab Invest 90 1: Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7 1: Mol Cancer Res 10 4: PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome.

J Pathol 1: No requirement for V D J recombination in pdeficient thymic lymphoma. Mol Cell Biol 18 6: Clinicopathological correlations and therapeutical implications. Int J Cancer 6: Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts. The pdelta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.

Nat Med 20 3: Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice. Physiol Genomics 31 2: Cardiac apoptosis in severe relapsing fever borreliosis. Infect Immun 73 Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice. ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors.

Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PLoS One 7 6: Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell 7 6: Memo is a copper-dependent redox protein with an essential role in migration and metastasis. Acute graft rejection of human fetal pancreas allografts using donor-specific human peripheral blood lymphocytes in the SCID mouse.

Split tolerance between spleen and lymph node cells in severe combined immunodeficiency mice grafted with AKR fetal liver cells. Int Immunol 6 8: Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 3 Pt 1: Stem Cells 34 9: Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev Immunol 3 3: Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.

Matrix metalloproteinase 9 MMP-9 is upregulated during scarless wound healing in athymic nude mice. Matrix Biol 25 8: Cancer Cell 30 3: Eur J Immunol 44 4: Reprogramming adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection. Generation of mouse models for type 1 diabetes by selective depletion of pancreatic beta cells using toxin receptor-mediated cell knockout. Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization. Infect Immun 72 Cancer Cell 19 3: Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.

Mol Cell 69 4: Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. A novel immunodeficient NOD. SCID-rd1 mouse model of retinitis pigmentosa to investigate potential therapeutics and pathogenesis of retinal degeneration. Biol Open 6 4: NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. PLoS Pathog 6 5: Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus.

PLoS One 12 3: Identification of a B-1 B cell-specified progenitor. Nat Immunol 7 3: Nat Genet 17 4: Comp Med 51 6: Mutations in the p53 and SCID genes cooperate in tumorigenesis.

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Priming and effector dependence on insulin B: J Clin Invest 7: Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells. PLoS One 13 6: Cell Death Differ 12 2: Homeostatic regulation of intestinal villous epithelia by B lymphocytes. Intestinal gammadelta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. Strain-dependent leakiness of mice with severe combined immune deficiency. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection.

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cell Microbiol 8 4: STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease.

Int Immunol 9 9: Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo. High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase. Translocation of bacteria from the gastrointestinal tract in immunodeficient mice.

Lab Anim 30 1: Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells. Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. Biochem Biophys Res Commun 2: Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells.

Infect Immun 81 Dynamics and localization of early B-lymphocyte precursor cells pro-B cells in the bone marrow of scid mice. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. Inhibitors of tyrosine phosphatases and apoptosis reprogram lineage-marked differentiated muscle to myogenic progenitor cells. Chem Biol 18 9: Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.

Pro-neural miR is a glioma tumor suppressor that targets mitogenic kinases. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb.

Cancer Cell 30 6: Cell Metab 25 5: T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes.

Letters From the Ledge - EBM (pt. 1)

EMBO J 25 4: PLoS One 12 8: Vet Pathol 31 1: Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons. J Neuroimmunol Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Adenovirus early region 3 antiapoptotic Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection.

Eur J Immunol 41 1: The nonobese diabetic scid mouse: Suppression of experimental colitis by intestinal mononuclear phagocytes. J Leukoc Biol 80 4: Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 15 2: PLoS One 11 3: Ability of spleen, peritoneal cavity, and lymph node B cells to reconstitute serum immunoglobulin in SCID mice.

Mol Immunol 31 Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells. Infect Immun 73 2: Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency scid mutation or X-linked immunodeficiency xid defect. Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.

Plk4 is required for cytokinesis and maintenance of chromosomal stability. Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice. Nat Med 21 8: Lethal exacerbation of Pneumocystis carinii pneumonia in severe combined immunodeficiency mice after infection by pneumonia virus of mice. Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res 70 3: Interleukin and host defense against murine Pneumocystis pneumonia. Infect Immun 76 5: Unexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice.

Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice. Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment.

J Bone Miner Res 26 7: Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells. Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate.

Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice. Infect Immun 76 1: Specific inhibition of autoimmune T cell transmigration contributes to beta cell functionality and insulin synthesis in non-obese diabetic NOD mice. Contribution of Fas to diabetes development. EMBO J 22 9: Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice. Infect Immun 65 8: Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: Cutaneous inflammatory disorder in integrin alphaE CD -deficient mice.

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.

Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice. Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient scid mice. J Neurosci 19 Eur J Immunol 45 7: Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.

Mol Immunol 44 Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model. J Infect Dis 2: SCID-bg mice as xenograft recipients.

The Labbitt Halsey Protocol, a novel

Lab Anim 31 2: Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos. Int J Radiat Biol 73 6: Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.

Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: Cancer Res 69 6: J Virol 71 4: Wnt signaling though beta-catenin is required for prostate lineage specification. A new immuno-, dystrophin-deficient model, the NSG-mdx 4Cv mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation. Stem Cells 31 8: J Immunol 6: Imiquimod inhibits melanoma development by promoting pDC cytotoxic functions and impeding tumor vascularization.

J Invest Dermatol J Immunol 1: Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8 6: Safety and efficacy of a tCD25 preselective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells. Stem Cells 33 3: J Exp Med Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice.

J Immunol 4: Cancer Cell 28 6: Interleukin plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Survival advantage of both human hepatocyte xenografts and genome editedhepatocytes for treatment of alpha-1 antitrypsin deficiency Mol Ther:. Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. T-helpercell cytokines drive cancer into senescence. J Immunol Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.

Cell Stem Cell 15 6: Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis. J Allergy Clin Immunol 3: IL blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation. Exp Hematol 35 Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. PLoS One 10 6: LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion. Stem Cells 32 4: The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes. J Immunol 7: Division and apoptosis of E2f-deficient retinal progenitors. Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. PLoS One 11 8: Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development.

J Immunol 3: Polyclonal breast cancer metastases arise from collective dissemination of keratin expressing tumor cell clusters. Bacteria activate sensory neurons that modulate pain and inflammation. Clin Immunol 3: Bcl-xL promotes metastasis independent of its anti-apoptotic activity. Cancer Res 71 8: Cancer Res 76 Expanding antigen-specific regulatory networks to treat autoimmunity.

Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells 31 5: A committed precursor to innate lymphoid cells. A unique function for cyclin D3 in early B cell development. Nat Immunol 7 5: Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell 15 2: Myeloid Engraftment in Humanized Mice: Stem Cells Dev 25 7: Human immune system development and survival of non-obese diabetic NOD -scid IL2rgamma null NSG mice engrafted with human thymus and autologous haematopoietic stem cells.

Clin Exp Immunol 3: Clin Exp Immunol 2: Pevonedistat, a NEDD8-activating enzyme inhibitor, is active in mantle cell lymphoma and enhances rituximab activity in vivo. Sci Transl Med 7 Cancer Res 77 Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. J Clin Invest 5: Donor SIRPalpha polymorphism modulates the innate immune response to allogeneic grafts.

Sci Immunol 2 PLoS One 6 5: Functional skeletal muscle regeneration from differentiating embryonic stem cells. Nat Med 14 2: J Leukoc Biol 88 3: Cell Metab 25 6: The Src and c-Kit kinase inhibitor dasatinib enhances pmediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen. Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells.

Nat Immunol 17 1: Medium conditioned with mesenchymal stromal cell-derived osteoblasts improves the expansion and engraftment properties of cord blood progenitors. Exp Hematol 42 9: Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. IL initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp Nat Immunol 11 Sci Signal 7 Mesenchymal stem cells express serine protease inhibitor to evade the host immune response. Anti-CD20 antibody therapy and susceptibility to Pneumocystis pneumonia.

Infect Immun 83 5: Cancer Cell 30 2: Lymph node-independent liver metastasis in a model of metastatic colorectal cancer. Sci Transl Med 8 Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium. Am J Pathol 1: Active hexose-correlated compound enhances extrinsic-pathway-mediated apoptosis of Acute Myeloid Leukemic cells.

PLoS One 12 7: Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. Macrophages eat cancer cells using their own calreticulin as a guide: Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. A function for interleukin 2 in Foxp3-expressing regulatory T cells.

Nat Immunol 6 Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance. Ischemic neurons recruit natural killer cells that accelerate brain infarction. NK and NKT cell-independent contribution of interleukin to innate protection against mucosal viral infection.

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J Virol 79 7: Identification of a cell of origin for human prostate cancer. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Cancer Cell 33 6: Humanized Mice in Dermatology Research. Role of type I interferon receptor signaling on NK cell development and functions. PLoS One 9 Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor.

Nat Immunol 10 2: Cell Rep 17 5: Intestinal mast cell progenitors require CD49dbeta7 alpha4beta7 integrin for tissue-specific homing. J Exp Med 9: Phosphoinositide 3-kinase beta mediates microvascular endothelial repair of thrombotic microangiopathy. STAT5-regulated microRNAb controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.

J Clin Invest 9: Nicotinic receptor beta2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer. PLoS One 8 2: Development and differentiation of early innate lymphoid progenitors. J Exp Med 1: Cancer Cell 21 4: Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Cell Rep 5 5: Effects of angiopoietinblocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 6: Nat Biotechnol 28 8: Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.

Macrophages prevent human red blood cell reconstitution in immunodeficient mice. The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation. J Biol Chem Antibody repertoires in humanized NOD-scid-IL2Rgamma null mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One 7 4: Cell Rep 16 3: PLoS One 4 Nat Med 16 2: Tuning sensitivity to IL-4 and IL Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.

Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. Alternative splicing of helicase-like transcription factor Hltf: Intron retention-dependent activation of immune tolerance at the feto-maternal interface. PLoS One 13 7: Cancer Cell 22 2: Interleukinproducing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med 20 1: FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. PLoS One 8 1: Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.

Clin Exp Immunol 1: Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2. Cancer Cell 24 5: Role of M2b macrophages in the acceleration of bacterial translocation and subsequent sepsis in mice exposed to whole body [Cs] gamma-irradiation. Identification of a T lineage-committed progenitor in adult blood.

ABCB5 is a limbal stem cell gene required for corneal development and repair. Contribution of IL to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins. Int Immunol 22 7: The clinical and immunological performance of 28 days survival model of cecal ligation and puncture in humanized mice. Cell Rep 15 Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model.

Cancer Cell 21 2: Mol Ther 23 Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nat Neurosci 19 2: Cancer Res 75 8: Nat Med 21 6: J Virol 86 6: Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells. Exp Hematol 37 8: Mol Ther Methods Clin Dev 7: Accelerated development of chronic lymphocytic leukemia in New Zealand Black mice expressing a low level of interferon regulatory factor 4.

IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development. Leukemia regression by vascular disruption and antiangiogenic therapy. Cell Rep 15 8: Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood.

Cell Stem Cell 1 6: Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-alpha, interferon-gamma and interleukin J Virol 86 1: The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. T cell costimulation with anti-CD monoclonal antibodies is mediated by Kpolyubiquitin-dependent signals from endosomes. Cell competition is a tumour suppressor mechanism in the thymus.

Thymus-autonomous T cell development in the absence of progenitor import. J Exp Med 8: Eur J Immunol 37 9: Dig Dis Sci 59 6: Conditional deletion of cytokine receptor chains reveals that IL-7 and IL specify CD8 cytotoxic lineage fate in the thymus. Comparison of human cord blood engraftment between immunocompromised mouse strains. Stem Cell Reports 4 2: Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection. J Exp Med 7: J Immunol 9: Humanized mice show clinical signs of dengue fever according to infecting virus genotype.

J Virol 83 Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Both stromal cell and colonocyte epidermal growth factor receptors control HCT colon cancer cell growth in tumor xenografts. Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: J Immunol 2: The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis.

Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma Cbl and Cbl-b in hematopoietic stem cells. Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids. Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma null mice engrafted with human peripheral blood mononuclear cells. Dis Model Mech 6 1: Cancer Cell 29 6: Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation.

T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Cancer immunoediting by the innate immune system in the absence of adaptive immunity. Non-self recognition by monocytes initiates allograft rejection. J Clin Invest 8: Nat Immunol 2 Implications for gene therapy-limiting expression of IL-2Rgammac delineate differences in signaling thresholds required for lymphocyte development and maintenance.

Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice. Clin Immunol 2: Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFbeta3-knockout mice alleles: Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development. DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis. Creation of 'humanized' mice to study human immunity. Curr Protoc Immunol Chapter A new immunodeficient hyperglycaemic mouse model based on the Ins2 Akita mutation for analyses of human islet and beta stem and progenitor cell function.

Loss of immune tolerance to IL-2 in type 1 diabetes. Regulation of peripheral T cell activation by calreticulin. Systemically dispersed innate ILexpressing cells in type 2 immunity. GABA promotes human beta-cell proliferation and modulates glucose homeostasis. Cell Rep 4 3: Protein tyrosine phosphatase-sigma regulates hematopoietic stem cell-repopulating capacity. J Clin Invest 1: Efficient tumour formation by single human melanoma cells. ILC regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol 12 Sci Signal 8 The lymphopenic environment of CD common gamma-chain -deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL J Immunol 8: PLoS One 11 2: Am J Pathol 6: The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.

PLoS One 5 PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Genes Dev 30 Cell Rep 16 9: Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. J Virol 90 Premyogenic progenitors derived from human pluripotent stem cells expand in floating culture and differentiate into transplantable myogenic progenitors. Sci Rep 8 1: Cancer Res 76 9: Nat Immunol 10 1: Sci Rep 7 1: De novo formation of the biliary system by TGFbeta-mediated hepatocyte transdifferentiation.

Nat Cell Biol 16 Eur J Immunol 42 4: The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor. Nat Immunol 16 6: Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Sci Transl Med 10 Retroviruses use CDmediated trans-infection of permissive lymphocytes to establish infection. Humanized mice in translational biomedical research.

Nat Rev Immunol 7 2: Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma null mice. A Hitchhiker's guide to humanized mice: Photochemical internalization of CDtargeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta 8: Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components.

J Exp Med 6: Cancer Cell 32 5: Janus kinase 3 Jak3 is essential for common cytokine receptor gamma chain gamma c -dependent signaling: Int Immunol 12 2: Lymphoid tissue inducer-like cells are an innate source of IL and IL Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells.

Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. PLoS Pathog 11 7: Stem Cells 34 2: The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemia. Exp Hematol 35 4: PLoS One 8 9: Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly.

Exp Hematol 42 4: Sepsis-induced human lymphocyte apoptosis and cytokine production in 'humanized' mice. J Leukoc Biol 86 2: Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus. PLoS One 9 1: Cancer Cell 26 1: Unique subset of natural killer cells develops from progenitors in lymph node. Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Res 74 Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection. Kit is essential for PMA-inflammation-induced mast-cell accumulation in the skin.

Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7R alpha, terminal deoxynucleotidyltransferase, and c mu expression.

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Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat Med 21 5: J Clin Invest 4: An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance. J Clin Invest 3: Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B.

Nat Commun 8 1: The effects of IL2Rgamma knockout on depression and contextual memory. Behav Brain Res 2: OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell 14 1: Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG Stem Cells 33 2: J Exp Med 3: Jak3 negatively regulates dendritic-cell cytokine production and survival.

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. Cancer Res 71 GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2. Cancer Res 74 4: TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol 16 Bat-mouse bone marrow chimera: Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell 16 3: Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection. Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells.

J Cell Sci Pt 7: Blood monocytes consist of two principal subsets with distinct migratory properties. Cancer Cell 27 3: A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation. Genes Dev 29 An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells. Eur J Immunol 27 9: Adaptive immune responses fail to provide protection against genital HSV-2 infection in the absence of IL Cancer Cell 3 1: Identification of a microRNA signature of renal ischemia reperfusion injury.

Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion. Eur J Immunol 43 1: Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain. Br J Haematol 2: Strength and corticosteroid responsiveness of mdx mice is unchanged by RAG2 gene knockout. Neuromuscul Disord 17 5: Eur J Immunol 39 4: Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation.

Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses. Infect Immun 81 3: CTLA-4 regulates induction of anergy in vivo. Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells. Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection.

J Virol 73 6: Genes Dev 10 Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice. Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus. Eur J Immunol 31 9: Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD on the pancreatic beta-cells.

Cell Rep 21 9: Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage. Eur J Immunol 44 1: Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. Nat Immunol 6 5: Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination.

Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J 27 Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor. MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis. Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor.

The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Cerebral expression of interleukin induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice.

Am J Pathol 3: Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes. Myb proteins regulate expression of histone variant H2A. Z during thymocyte development. Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol 7 8: IL transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo. Int Immunol 21 6: Arginine methylation of the B cell antigen receptor promotes differentiation.

A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice. PLoS One 9 8: Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1. EMBO J 21 Three-dimensional visualization of the mouse thymus organization in health and immunodeficiency. PLoS One 7 Contribution of ILinduced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. Int Immunol 18 6: Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjogren's syndrome-like autoimmune exocrinopathy.

Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. Nat Immunol 6 2: Allele-specific regulation of TCR beta variable gene segment chromatin structure. PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice. Interaction of Ras with Pgamma Is required for thymic beta-selection in the mouse.

Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. Nat Immunol 11 7: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.

Nat Immunol 10 8: MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis. Genes Dev 28 An animal model of hemophagocytic lymphohistiocytosis HLH: J Leukoc Biol 91 5: Mol Cancer Res 11 PLoS Pathog 9 1: J Leukoc Biol 83 5: Arterioscler Thromb Vasc Biol 25 4: In vivo-generated antigen-specific regulatory T cells treat autoimmunity without compromising antibacterial immune response.

Sci Transl Med 6 Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Mol Cell Biol 32 Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice. Impaired expansion of mouse B cell progenitors lacking Btk.

PLoS Pathog 11 3: Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PDmediated signaling. MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling. GPRmediated homing controls immune homeostasis in the large intestine mucosa. Int Immunol 22 Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. A crucial role for B cells in neuroinvasive scrapie [see comments] Nature Cellular and molecular requirements for rejection of b16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation.

Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors. Adaptive immunity maintains occult cancer in an equilibrium state. Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro. The Foxp3 target miR contributes to the development of regulatory T cells. Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow.

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell 24 2: Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint. Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo. Possible involvement of glial cell line-derived neurotrophic factor and its receptor, GFRalpha1, in survival and maturation of thymocytes.

Eur J Immunol 33 8: Thymocyte apoptosis drives the intrathymic generation of regulatory T cells. Eur J Immunol 35 The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo. Sci Signal 6 Targeted Sos1 deletion reveals its critical role in early T-cell development. Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition. Int Immunol 13 4: Follicular dendritic cells emerge from ubiquitous perivascular precursors. Infect Immun 80 8: Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model.

Transcriptional control of rapid recall by memory CD4 T cells. CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism. Characterization of T cell differentiation in the murine gut. A multivariable optimization approach. Clin Immunol 1: Ig heavy chain class switching in Rag-deficient mice.

Int Immunol 10 3: PLoS One 11 4: New insights into the proliferation and differentiation of early mouse thymocytes. Int Immunol 16 8: The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells. Nat Immunol 10 3: A p85alpha-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells. Nat Immunol 16 1: Mobilization of natural killer cells inhibits development of collagen-induced arthritis. Infect Immun 75 6: Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas.

Developmental control of integrin expression regulates th2 effector homing. B7-h1 programmed cell death ligand 1 is required for the development of multifunctional Th1 cells and immunity to primary, but not secondary, salmonella infection. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res 21 Regulation of thymocyte development through CD3: J Clin Invest Increased susceptibility to Salmonella infection in signal regulatory protein alpha-deficient mice. Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes.

Cell Growth Differ 7 1: Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival. Mol Cell Biol 30 3: No requirement for V D J recombination in pdeficient thymic lymphoma. Mol Cell Biol 18 6: Epidermal EGFR controls cutaneous host defense and prevents inflammation. Sci Transl Med 5 Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. J Mol Cell Cardiol 44 2: Densely granulated murine NK cells eradicate large solid tumors. Cancer Res 72 8: The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis.

PLoS One 6 3: Nat Med 20 3: Eur J Immunol 43 2: Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.

CTLA-4 ablation and interleukin driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes. Circ Res 3: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. In vivo fate mapping identifies pre-TCRalpha expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis.

T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. PreTCR and TCRgammadelta signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization. Sci Signal 4 Blockade of CDCD27 interaction inhibits induction of allergic lung inflammation in mice. Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.

Nat Immunol 11 2: Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer.


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Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. Exp Hematol 32 8: Eur J Immunol 43 6: Anti-CD3epsilon mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. A novel model for lymphocytic infiltration of the thyroid gland generated by transgenic expression of the CC chemokine CCL Maintenance of surrogate light chain expression induces developmental delay in early B cell compartment.

Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res 68 Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist. PLoS Pathog 7 T-cell function is critical for murine cholesterol gallstone formation. A novel immunodeficient mouse model--RAG2 x common cytokine receptor gamma chain double mutants--requiring exogenous cytokine administration for human hematopoietic stem cell engraftment.

J Interferon Cytokine Res 19 5: PLoS Pathog 9 6: Impaired social recognition memory in recombination activating gene 1-deficient mice. The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells. EMBO J 30 Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.

Improved regeneration after femoral nerve injury in mice lacking functional T- and B-lymphocytes. Int Immunol 19 Reversion of B cell commitment upon loss of Pax5 expression. Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease. Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta.

Nat Immunol 14 1: Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Mechanisms of oncostatin M-induced pulmonary inflammation and fibrosis. Eur J Immunol 39 The RhoA transcriptional program in pre-T cells. FEBS Lett Cell Immunol 1: V D J recombination is not required for the development of lymphoma in pdeficient mice. Cell Growth Differ 9 2: Infect Immun 76 6: Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X.

Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease. Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med 8 6: Homeostatic regulation of intestinal villous epithelia by B lymphocytes. EMBO Rep 16 5: Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes.

Lipopolysaccharide induces intestinal glucocorticoid synthesis in a TNFalpha-dependent manner. Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. PLoS Pathog 9 7: Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Int Immunol 23 5: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 [see comments] Nature Cancer immunoediting of the NK group 2D ligand H60a. Dendritic cells suppress IgE production in B cells. Int Immunol 19 2: IL is a crucial amplifier of innate rather than acquired immunity.

J Invest Dermatol 3: Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry. Basophil effector function and homeostasis during helminth infection. Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells. Infect Immun 81 Cancer Res 65 Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-beta in gastric tissue.

Cancer Res 74 9: JunB is a gatekeeper for B-lymphoid leukemia. IL regulates the immune response to inhaled antigens. Nat Immunol 8 SHP1 complex promotes T-cell survival. EMBO J 34 3: PLoS One 12 8: EMBO J 25 4: H3K4 tri-methylation provides an epigenetic signature of active enhancers. Nat Immunol 5 6: Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors.

Integrative biology approach identifies cytokine targeting strategies for psoriasis. Disruption of IL signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria. Elucidation of IgH intronic enhancer functions via germ-line deletion. Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity.

Generation of a mouse expressing a conditional knockout of the hepatocyte growth factor gene: DNA Cell Biol 23 9: Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation. Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

Nat Immunol 13 6: Molecular and cellular aspects of induced thymus development in recombinase-deficient mice. Eur J Immunol 29 8: Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression. Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity. Infect Immun 79 7: Regulation of thymus size by competition for stromal niches among early T cell progenitors.

Developmental stage-dependent collaboration between the TNF receptor-associated factor 6 and lymphotoxin pathways for B cell follicle organization in secondary lymphoid organs. A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.

Nat Immunol 12 7: Trans-endocytosis of CD80 and CD The PI3K isoforms palpha and pdelta are essential for pre-B cell receptor signaling and B cell development. Sci Signal 3 IL availability conditions homeostasis of peripheral natural killer T cells. IL is an essential mediator of peripheral NK-cell homeostasis. Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice.

Arterioscler Thromb Vasc Biol 21 6: Endotoxin shock in antibody-deficient mice: Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection. Eur J Immunol 30 5: NK cell regulation of CD4 T cell-mediated graft-versus-host disease. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. Exp Hematol 34 3: Adaptive immunity does not strongly suppress spontaneous tumors in a sleeping beauty model of cancer.

NK cell responses to Plasmodium infection and control of intrahepatic parasite development. Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene. Nat Immunol 6 1: Infect Immun 75 Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response. The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes. Biochim Biophys Acta B-cell development fails in the absence of the Pbx1 proto-oncogene.

Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat Immunol 9 4: Disparate peptide-dependent thymic selection outcomes in beta2M-deficient mice versus TAPdeficient mice: Eur J Immunol 33 2: Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation. J Virol 74 Mol Cell 34 3: Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.

Cellular cross talk in the small intestinal mucosa: The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain. The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas.

Stage-specific control of early B cell development by the transcription factor Ikaros. Nat Immunol 15 3: Brain Behav Immun 17 5: Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes. Toxicol Appl Pharmacol 1: IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Tumor necrosis factor alpha inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis.

PLoS One 7 5: Deregulated TCR alpha beta T cell population provokes extramedullary hematopoiesis in mice deficient in the common gamma chain. Eur J Immunol 27 4: Granzyme B, a new player in activation-induced cell death, is down-regulated by vasoactive intestinal peptide in Th2 but not Th1 effectors. Antibody production in early life supported by maternal lymphocyte factors. Biochim Biophys Acta 1: TRAF6 directs commitment to regulatory T cells in thymocytes.

Genes Cells 16 4: Int Immunol 6 7: The p85alpha regulatory subunit of class IA phosphoinositide 3-kinase regulates beta-selection in thymocyte development. Dendritic cells require T cells for functional maturation in vivo. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut.

Nat Med 17 Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4 6: Establishment and characterization of RAG-2 deficient non-obese diabetic mice. Scand J Immunol 43 5: Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity.

Cancer Cell 31 5: Developmental arrest of T cells in Rpldeficient mice is dependent upon multiple p53 effectors. The role of homotypic interactions in the differentiation of B cell precursors. Eur J Immunol 31 4: Lymphocytes support oval cell-dependent liver regeneration.