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Table of contents
- The New Zealand Digital Library Project
- Publications since 2014
- How Not to be Wrong
- Buy How Not To Be Wrong By Jordan Ellenberg | Nuria Kenya
- Phylogeography and Conservation Biology
Winter Council meeting: outcomes Intermedex adjustments, longer postdoc contracts, and some dates for your diaries More on page 2. Health insurance As of the ratio of EMBL Health Insurance Scheme contributions will change to a third for employee and two thirds for employer — as was the case prior to — which means that the contribution paid by staff increases by 0.
Additionally, new provisions on additional reimbursement, physiotherapy and kinesitherapy, and dental prostheses and dentofacial orthopedic treatment will apply on all treatment taken after 1 January.
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All medical bills should be sent directly to the patient for authorisation before payment by Intermedex. Postdoc contracts EMBL Council decided to increase the standard initial period of EMBL postdoc contracts from one to two years and to extend the maximum normal duration of the fellowships from four to five years. Other news The Genomics Core Facility has permission to purchase two new generation genome analyser sequencing systems to meet the strong demand for this technology.
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These are features it shares with more complex organisms. Right: Bernd-Uwe second from right and two of his sons and daughters-in-law enjoying a skiing holiday. His professional life often entailed lots of travelling, staying away from home and his family — and Bernd-Uwe is a real patriarch. During his time, new personnel and financial systems were implemented and processes now run much more smoothly, providing useful and valued services to the scientists.
I want to spend as much time as I can with my growing number of grandchildren.
See page 11 for more details. EMBL intranet: we want your news! Got some news to convey to the EMBL community? More immediate and flexible than the newsletter, it offers a further opportunity to present your news to the rest of EMBL.
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As scientific stories are already covered in the Press Releases section, the types of articles covered in News might include retreat announcements, building inaugurations, awards and achievements, new people at EMBL, or announcements about new initiatives or services. The news appears on the intranet pages at Heidelberg, Grenoble, Hamburg and Monterotondo, so articles of interest to the entire EMBL community are ideal. If you have any news that should be considered for the EMBL intranet, please write to info embl.
No full-frontal nudity please! Would you want to live a longer life?
Publications since 2014
If you could avoid some of the potential downsides to ageing, such as weaker bones and memory loss, perhaps. In a study mimicking the effects of calorie restriction, scientists reared long-lived mice that were fitter and suffered fewer age-related disorders than ordinary mice. The UCL researchers bred mice that were unable to produce S6 Kinase 1 S6K1 — a key protein in a nutrient-sensing pathway that enables them to respond appropriately to changing food levels.
The popular lunchtime demonstration session also gave visitors the chance to quiz the experts face-. The next will be held on 4 March To register, please visit www. With the planned new teaching and research buildings, recreational facilities and meeting places for researchers, transport links and sustainable housing, it is projected that the site will welcome 20, scientists and students and 10, inhabitants by the year They were less likely to develop type 2 diabetes and had better balance, strength and coordination.
If mice can live longer, why not humans? Although this would be challenging to study experimentally, bioinformatics could continue to provide useful insights; comparisons of the pathway in mice and humans could shed light on whether they share similar mechanisms, for example. Looking further forward, software may one day be able to model how calorie restriction may affect humans, or to search for potential drug targets in the S6K1 pathway that could assist healthy ageing.
I went back and forth for many years, and then slowly realised that it was where I wanted to be. It was like self-discovery. I decided that I wanted to live in the Himalayas, and I was 30 when I decided to become a monk. How did you become the French interpreter for the Dalai Lama? So I became his interpreter. How did that come about? Their research projects investigate the neurobiological effects of meditation on long.
How did it feel then to go back to the lab? Frankly, it was mostly fun. I take part in the exciting parts and not the tedious ones. How would you describe the relationship between Buddhism and science? The universe being created in seven days is a big problem for science. The Buddhists added cosmology, which was borrowed from the Hindus — not a big deal.
We drop it, no problem — nobody minds. The main thing is about the mind, about changing the mind and the science of mind.
You were once labelled the happiest person in the world. Of course I have a higher amplitude than most other subjects, but it has nothing to do with happiness. Is there anything that really annoys you? Sometimes I get a bit anxious, like when I nearly miss a plane — but so what? You just need to free yourself from that. From fruit fly wings to heart failure — why Not ch?
EMBL scientists have been the first to link a key signalling pathway to heart development and healing, indicating that it may play an important role in heart attack recovery. Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway — a molecular mechanism through which cells communicate — has been proven to target heart muscle cells. When they inactivated Notch specifically in the heart muscle precursor cells of early. Curiously, increasing Notch signalling in the heart muscle cells of older embryos had the same detrimental effect, uncovering different requirements for Notch as development proceeds.
Intriguingly, the scientists were able to improve the cardiac function and survival rate of adult mice that had suffered heart attacks by re-activating Notch, suggesting new therapeutic approaches to help the heart recover from damage. With research collaborations, conferences, technology exchange and outreach initiatives — such as Science in School, Science on Stage see box, right and the new EIROforum Teacher School series, the first of which recently took place at CERN — the partners mobilise their expertise in basic research and in the management of large international infrastructures to benefit European research and development.
FEBS Letters , 19 , Sindy Neumann, Dieter Langosch. Conserved conformational dynamics of membrane fusion protein transmembrane domains and flanking regions indicated by sequence statistics. Proteins: Structure, Function, and Bioinformatics , 79 8 , Simone Kosol, Klaus Zangger. Dynamics and orientation of a cationic antimicrobial peptide in two membrane-mimetic systems.
Journal of Structural Biology , 1 , Dieter Langosch, Jana R. Herrmann, Stephanie Unterreitmeier, Angelika Fuchs. Helix-helix interaction patterns in membrane proteins. Journal of Biological Chemistry , 18 , Yanqiu Wu, Steve C. Shih, Natalie K.
How Not to be Wrong
Probing the structure of the Ff bacteriophage major coat protein transmembrane helix dimer by solution NMR. Pair your accounts. Your Mendeley pairing has expired. Please reconnect. This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. I would eventually learn that many people with the onset of a chronic disease in adulthood had brief periods of symptoms years and often decades before actual onset. Because T1D most commonly begins in childhood and antibodies can arise a long time before clinical symptoms ever begin, scientists looked for risk factors occurring very early in life, including during pregnancy and birth.
Gisela Dahlquist is a Swedish diabetes researcher who has looked into such non-genetic risk factors. Sweden collects data from pregnancy and birth in population-wide registries and also tracks diagnoses of T1D and other health conditions later in life. Dahlquist and her group 19 Dahlquist, G.
Kallen Dahlquist et al wondered whether the common element for many of the prenatal risk factors they had identified was that they each represented some form of prenatal stress.
Buy How Not To Be Wrong By Jordan Ellenberg | Nuria Kenya
It was a whole new way of looking potential causes of type 1 diabetes. When I was a family doctor I followed women during pregnancy and helped them deliver their babies. These events were all considered pretty common on the labor and delivery floor of the hospitals I worked in, but nurses and other doctors and family members were always a little uncomfortable and concerned until we knew that everything had turned out okay.
Even though most babies seemed to recover fully with a little time, I always wondered whether there were any long-term consequences we were overlooking. So I was really curious whether there was any research on this topic once I started learning there were studies.
I found many important bodies of research examining the role of prenatal events in risk for chronic illness.
Phylogeography and Conservation Biology
Devaskar The hypothesis comes from a large series of prospective and now multigenerational studies showing links between prenatal events and adult health. The original study followed babies whose mothers experienced starvation during a siege in World War II known as the Dutch Hunger Winter. Their findings have been widely replicated and show that different types of prenatal stress can all result in the metabolic syndrome and other chronic illnesses.
FOAD increases risk for diseases such as see summary of the research Table 1 :. Additional research shows that many kinds of stressful events in early life also increase risk for autoimmune and other chronic diseases. It has also been suggested that events occurring during the prenatal time frame are associated with risk for lupus 34 Edwards, C.
James Dietert It is also one of the causes of jaundice in newborns. Dahlquist replicated this in a study with T1D-prone mice by removing the pups from their cages for two 4-hour periods a day for 5 days in their first few days of life 37 Dahlquist, G. She had a control group that stayed with their dams and two treatment groups: one treated with light therapy and the other with a sham treatment. A significant percentage of the treated group who survived developed T1D. Dalhquist discovered that the risk factor for T1D was not the treatment, the jaundice, nor the blood group incompatibility.
To her surprise, it was the separation of mice pups from their mothers that influenced risk for T1D. Some of the first research I discovered regarding the role of separation between mothers and their babies was conducted by Columbia University professor and physician Myron Hofer 38 Hofer, M.