Biomedical Polymers and Polymer Therapeutics

Biomedical Polymers and Polymer Therapeutics: Medicine & Health Science Books @ leondumoulin.nl
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Polymers and polymer systems for targeted drug delivery polymer therapeutics This project encompasses the study of the relationship between the structure, physico-chemical and biological properties of water-soluble polymers or supramolecular structure-forming polymer drug carriers and carriers of other biologically-active molecules designed as polymer therapeutics suitable for utilization in human medicine.

Special attention is paid to the development of polymer anti-tumour drugs delivering polymer-bound cytotoxic drugs into solid tumours or to the receptors expressed in a membrane of the tumour cells and enabling cellular internalization and intracellular controlled release and activation of the delivered drugs. Synthesis of the polymer drugs is based on conjugation of reactive copolymers — polymer precursors — with targeting moieties and other biologically-active molecules drugs.

The structures of the polymer carriers are based on water-soluble N- 2-hydroxypropyl methacrylamide HPMA copolymers forming polymer chains of various architecture or amphiphilic copolymers forming supramolecular and micellar structures in an aqueous environment.

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At present the following systems are under study: In these systems, the thermosensitivity of the system facilitates local therapy and long-term drug release. Hybrid macromolecular stimuli-resposive systems The aim of this project is the investigation of the associative behaviour of hydrophilic copolymers containing tailor-made multiple peptide blocks consisting of repeating pentapeptide or heptapeptide sequences, self-assembling into elastin-like structures or coiled coils in response to external stimuli changes in pH, temperature.

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Polymers and polymer systems for combined therapy and diagnosis This project deals with water-soluble polymers and polymer micellar systems as carriers enabling combined therapy and diagnosis. This type of polymer therapeutics is combining the activities of various ligands attached to the same carrier system. Polymer therapeutics combining the activity of two or more drugs differing in mechanism of action, activity of drug and radionuclide as radiotherapeutic or diagnostic or combining chemotherapy with hyperthermia, immunotherapy, radiotherapy or other clinical techniques are under study.

Biomedical Polymers and Polymer Therapeutics

Polymer-based antibody mimetics - iBodies We study in detail novel synthetic macromolecular systems iBodies based on water soluble N - 2-hydroxypropyl methacrylamide copolymers designed to fully substitute antibodies in common biochemical methods. We use cookies to give you the best possible experience. By using our website you agree to our use of cookies. Dispatched from the UK in 3 business days When will my order arrive? Mark W J Strachan.

Home Contact Us Help Free delivery worldwide. This book focuses on the progress and unique discoveries in the interdisciplinary scientific and technological area of biomedical application of polymers.


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The topics include polymeric materials for biomedical and pharmaceutical applications, as well as polymeric materials in therapeutics. Product details Format Paperback pages Dimensions Pharmacokinetics Made Easy Donald J.

Biomedical Polymers and Polymer Therapeutics - Google Книги

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How Does Polymer Therapeutics work?

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