The Neuregulin-I/ErbB Signaling System in Development and Disease: 190 (Advances in Anatomy, Embryol

The neuregulin-I/ErbB signaling system in development and disease. Adv Anat Embryol Cell Biol | Neuregulins (NRGs) comprise a large family of Review in Advances in anatomy, embryology, and cell biology · February.
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• Characterization of Glial Cell Models and In Vitro Manipulation of the Neuregulin1/ErbB System
• The neuregulin-I/ErbB signaling system in development and disease.
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Berlin ; New York: Advances in anatomy, embryology, and cell biology , v. English View all editions and formats Summary:. Find a copy online Links to this item Table of contents. Allow this favorite library to be seen by others Keep this favorite library private.

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Find a copy in the library Finding libraries that hold this item In contrast, the NRG1 proteins have been demonstrated to play important roles during the development of the nervous system, heart, and mammary glands. For example, NRG1 has essential functions in the development of neural crest cells and some of their major derivatives, like Schwann cells and sympathetic neurons. NRG1 controls the trabeculation of the myocardial musculature and the ductal differentiation of the mammary epithelium.

Moreover, there is emerging evidence for the involvement of NRG signals in the development and function of several other organ systems, and in human disease, including breast cancer and schizophrenia. Many different isoforms of the Neuregulin-1 gene are synthesized. Such isoforms differ in their tissue-specific expression patterns and their biological activities, thereby contributing to the great diversity of the in vivo functions of NRG1.

Neuregulins transmit their signals to target cells by interacting with transmembrane tyrosine kinase receptors of the ErbB family. No ratings or reviews yet.

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