Saving Lives, Saving Memories

SAVING MEMORIES WITH MORE THAN PHOTOS. Sep 2 Photos are usually the primary way people share events and tell stories.
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Procrastination is not an option!

To continue reading this article, please exit incognito mode or log in. Visitors are allowed 3 free articles per month without a subscription , and private browsing prevents us from counting how many stories you've read. We hope you understand, and consider subscribing for unlimited online access. Now research by scientists at Harvard and MIT suggests a potential new therapeutic approach. The researchers demonstrated that activating SIRT1 and injecting resveratrol, which have both been previously associated with life-span extension in lower organisms, can also prevent cognitive problems in the mice.

Saving Memories Forever

The mice used in the study develop an approximation of human neurodegenerative disease over a period of weeks. As neurons in their brains die and lose connections, their spatial learning is impaired, and the mice develop difficulty associating cause and effect.

Treatment with resveratrol reduced the death and degeneration of neurons in these mice and also restored their learning abilities to a level comparable to that of normal mice not suffering neurodegeneration. Tsai says this improvement in function suggests that resveratrol has potential for treating human neurodegenerative diseases.

Tsai is a scientific advisor to Sirtris. The study is the first to suggest that resveratrol could actually improve cognitive function in patients with neurodegenerative diseases. Guarente says the study suggests that compounds that can activate SIRT1 could be used to treat neurodegenerative disease in humans as long as they can pass through the blood-brain barrier.

Passion for Listening

This membrane surrounding and protecting the brain from chemicals in the blood presents a major challenge to any researcher developing drugs that target the brain. Mice in the study received injections of resveratrol directly into blood vessels in their brains, which would not be practical in human patients.

Previous studies have shown that resveratrol extends life span in yeast, roundworms, fruit flies, and fish. This gene is one of a family of genes called sirtuins that many researchers believe are master regulators of the aging process.


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By activating sirtuins, Sinclair, Guarente, and other researchers aim not to extend human life but to create new therapies for the diseases of aging. Be the leader your company needs.


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Everything included in Insider Basic, plus the digital magazine, extensive archive, ad-free web experience, and discounts to partner offerings and MIT Technology Review events. Whether you want to save just a few memories, a full life, or to commemorate the achievements of your company, we urge you to continue! T he help of a professional is just a call away.

Know someone who would benefit from being part of our tribe? Kit serves as personal historian for her business Firsthand Memories, which supports the gathering and preservation of life stories from individuals, veterans, and businesses. Kit draws on her organizational and project management skills honed while working previously in private business, where she specialized in data research and improving digital processing for both civilian and national defense mapping programs. Kit continues to hold certification in project management through the Project Management Insititute.

The chair of the local Colorado Personal Historians group since , Kit promotes and supports the activities of life story preservation colleagues in the Personal Historian industry. Why am I doing the business of Firsthand Memories? One day, in a fit of despair, and living thousands of miles from his daughters, he threw away over 25 boxes of slides that held most of the photos of their life together.

I was excited to find this forgotten item but worried that the tape might deteriorate if used. So, I quickly transformed that it onto digital media.

Thankfully, I could still hear their vibrant voices. It felt like they were in the room with me.