Biological Membrane Ion Channels: Dynamics, Structure, and Applications (Biological and Medical Phys

Biological Membrane Ion Channels: Dynamics, Structure, and Applications ( Biological and Medical Physics, Biomedical Engineering) [Shin-Ho Chung, Olaf S .
Table of contents

Membrane Proteins edited by J.

Ion channels: their structure, function and control – an overview

Gumbart and Sergei Noskov. Download high-res image KB Download full-size image. We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies. Author links open overlay panel Karunakar R. Under an Elsevier user license.

Mathematics of Quantum and Nano Technologies

Abstract Channels in the outer membrane of Gram-negative bacteria provide essential pathways for the controlled and unidirectional transport of ions, nutrients and metabolites into the cell. The role of the dielectric barrier in narrow biological channels: A novel composite approach to modeling single-channel currents.


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A comparative study of four computational methods. Gating gramicidin channels in lipid bilayers: Reaction coordinates and the mechanism of dissociation. Biophysical Journal 86, 92 The open state gating mechanism of gramicidin a requires relative opposed monomer rotation and simultaneous lateral displacement. Structure 14, Computational modeling of ion transport through nanopores Nanoscale 4, A molecular machine biosensor: Construction, predictive models, and experimental studies. Biosensors and Bioelectronics 34, A numerical method for cellular electrophysiology based on the electrodiffusion equations with internal boundary conditions at internal membranes.

Communications in Applied Mathematics and Computational Science 4, 85 A three-dimensional model of cellular electrical activity. Bulletin of the Institute of Mathematics, Academia Sinica 2, Hindered diffusion in polymer-tethered membranes: A monolayer study at the air-water interface. Biomacromolecules 2, Liebermann, and et al. The peptide-tethered lipid membrane as a biomimetic system to incorporate cytochrome c oxidase in a functionally active form.

Biosensors and Bioelectronics 14, Molecular biology meets microelectronics. Nature Biotechnology 19, Deamer, and et al. Replication of individual DNA molecules under electronic control using a protein nanopore. Nature Nanotechnology 5, Solution of the Poisson-Nernst-Planck equations in the cell-substrate interface. The European Physical Journal E: Soft Matter and Biological Physics 24, 1 Ion channels and lipid bilayer membranes under high potentials using microfabricated apertures.

Biomedical Microdevices 4, Supported hybrid bilayer membranes as rugged cell membrane mimics.


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    7. Langmuir 15, A new computational approach for electrical analysis of biological tissues. Bioelectrochemistry 59, 73 Influence of ion occupancy and membrane deformation on gramicidin a channel stability in lipid membranes. Biophysical Journal 61, Theoretical and computational models of biological ion channels.

    Quarterly Reviews of Biophysics 37, 15 Scientific and practical applications.

    Molecular dynamics simulations of membrane channels and transporters

    Science , 43 Voltage-dependent formation of gramicidin channels in lipid bilayers. Biophysical Journal 81, Framework model for single proton conduction through gramicidin. Biophysical Journal 80, 12 Derivation of Poisson and Nernst-Planck equations in a bath and channel from a molecular model. E 64, Analysis and simulation of semiconductor devices. Gated ion channel-based biosensor device. Krishnamurthy, editors, Biological Membrane Ion Channels, pages — Cui, and et al. A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. Testing the applicability of Nernst-Planck theory in ion channels: Comparisons with Brownian Dynamics simulations.

    Impedance analysis of supported lipid bilayer membranes: Biochimica et Biophysica Acta.

    Highlights

    Nano Letters 10, Shaw, and et al. Rapid detection and simultaneous subtype differentiation of influenza a viruses by real time pcr. Journal of Virological Methods , Recently, Ian Findlay has answered this question Findlay, Findlay and colleagues found that depolarization increased the probability that an ion channel shows rapid VDI before CDI.

    He also shows that VDI is modulated by protein kinase A-mediated phosphorylation. These findings are intriguing for understanding physiological functions of VDCCs in action potential formation. Kir channels are subject to various modulators, such as G-proteins or intracellular ATP. Their findings indicate that the control may not be restricted to K G channels, but may also affect other G-protein effects such as adenylyl cyclase and phospholipase C. Thus it may be of general importance in the control of G-protein-mediated signalling systems. This channel couples the cell metabolic state to membrane excitability.

    Susumu Seino has shown, by generating mice with one or other gene ablated, the physiological relevance of K ATP channels containing Kir6.


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    2. Ion channels: their structure, function and control – an overview?
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      7. He reported that Kir6. He and colleagues also showed that Kir6. It is also noteworthy that their Kir6.

      Biological Membrane Ion Channels Dynamics Structure and Applications Biological and Medical Physics

      ATP released from injured tissues is known to induce pain. The target of this ATP action is the P2X receptor, which constitutes a cation channel; activation by ATP causes a depolarization of peripheral afferent neurones. Alan North and colleagues have investigated the regulatory mechanisms of P2X receptor ion channels, since isolating the seven subunit cDNA clones North, They are especially interested in channels consisting of heteromultimers of P2X 2 and P2X 3 subunits, for which studies in P2X 3 -selective antagonists, antisense oligonucleotides and gene knock-outs support a role in neuropathic pain.

      By extensive use of the substituted cysteine accessibility method, they have deduced regions of the molecule that contribute to ion permeation and ligand binding.